Contact information

Zhucheng Chen Ph.D.

Professor | The National Science Fund for Distinguished Young Scholars


1994-1998Nankai University B.S.

1998-2001Peking University M.S.

2001-2003New York University M.S.

2003-2008Weill Cornell Graduate School of Medical Science Ph.D.

2008-2008Memorial Sloan-Kettering Cancer Center Postdoc.

2008-2011University of Texas Southwestern Medical Center Postdoc.

2011-2017School of Life Sciences, Tsinghua University Tenure-track associate professor

2020-PresentSchool of Life Sciences, Tsinghua University Professor

Main Research Fields

We use various tools in biophysics, including X-ray crystallography and electron microscopy,to study important molecular machines, chromatin regulators in particular.

Selected Publications

1. Yuan J#, Chen K#, Zhang W, Chen Z*. (2022) Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. Nature, 605(7908):166-171.
2. Wang L#, Chen K#, Chen Z*. (2021) Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nature Comm., 12 (1):4058.
3. Chen M#, Pan H#, Sun L#, Shi P#, Zhang Y, Li L, Huang Y, Chen J, Jiang P, Fang X, Wu C, Chen Z*. (2020) Structure and regulation of human epithelial cell transforming 2 protein. PNAS, 117(2):1027-1035.
4. Ye Y#, Wu H#, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR*, Gao N*, Chen Z*. (2019 ) Structure of the RSC complex bound to the nucleosome. Science, 66(6467):838-843.
5. Yan L#, Wu H#, Li X, Gao N*, Chen Z*. (2019) Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat. Struct. Mol. Biol., 26(4):258-266.
6. Li M# Xia X#, Tian Y#, Jia Q#, Liu X#, Lu Y, Li M*, Li X*, Chen Z*. (2019) Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567(7748):409-413.
7. Liu X#, Li M#, Xia X#, Li X*, Chen Z*. (2017) Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure Nature,544 (7651):440-445.
8. Yan L#, Wang L#, Tian Y, Xia X, Chen Z*. (2016) Structure and regulation of the chromatin remodeller ISWI. Nature,540(7633):466-469.
9. Xu P#, Li C#, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z*. (2016) The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. Mol. Cell., 63 (6):965-75.
10. Xia X#, Liu X#, Li T, Fang, X, Chen Z*. (2016) Structure of chromatin remodeller Swi2/Snf2 in the resting state. Nat. Struct. Mol. Biol., 23(8):722-9