Contact information

Yuanyuan Li Ph.D

2018 Advanced Innovation Young Scientist, Beijing Advanced Innovation Center For Structural Biology
2017 Beijing Nova Program
2017 Young Elite Scientists Sponsorship Program, China Association for Science and Technology
2016 The Journal of Biochemistry (JBC)/Herb Tabor Young Investigator Award
2016 Advanced Innovation Fellow, Beijing Advanced Innovation Center for Structural Biology


2002-2006Department of Biotechnology, Shandong University B.S.

2006-2011CAS IBP/Tsinghua University Ph.D.

2011-2017School of Medicine, Tsinghua University Postdoc.

2017-PresentSchool of Medicine, Tsinghua University Research assistant professor

Main Research Fields

1.Molecular studies of epigenetic regulation and human health and diseases.

2.Structure-based drug discovery of key epigenetic factors, e.g. YEATS domain proteins.

Selected Publications

1. Li X, Li XM, Jiang Y, Liu Z, Cui Y, Fung KY, van der Beelen She, Tian G, Wang L, Shi X, Allis CD, Li H, Li Y*, Li XD* (2018) Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking. Nat Chem Biol 14:1140-1149 (#co-corresponding author)

2. Wan L#, Wen H#, Li Y#, Lvu J, Xi Y, Hoshii T, Joseph J, Wang X, Loh Y, Erb MA, Souza AL, Bradner JE, Shen L, Li W, Li H, Allis CD*, Armstrong SA*, and Shi X#* (2017) ENL links histone acetylation to oncogenic gene expression in AML. Nature 543, 265-269 (#co-first author)

3. Li Y#, Sabari BR#, Panchenko T#, Wen H, Zhao D, Guan H, Wan L, Tang Z, Zhao Y, Roeder R. Shi X, Allis CD*, and Li H* (2016) Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain. Mol Cell 62:181-193 (#co-first author)

4. Li Y#, Wen H#, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SYR, Li W, Li H*, and Shi X* (2014) AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell 159:558-571 (#co-first author)

5. Wen H#*, Li Y#, Xi Y#, Jiang S, Stratton S, Peng D, Tanaka K, Ren Y, Xia Z, Wu J, Li B, Barton MC, Li W*, Li H*, and Shi X* (2014) ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Nature 507, 263-268 (#co-first author)