联系方式

邮箱:yixue@mail.tsinghua.edu.cn

薛毅博士

助理教授

个人履历

1993-1997清华大学现代应用物理系 学士

1997-1999福建实达电脑公司 工程师

2000-2003清华大学生物科学与技术系 硕士

2004-2009普渡大学化学系 博士

2010-2013普渡大学化学系 博士后

2013-2016密歇根大学/杜克大学 博士后

2016- 至今清华大学生命科学学院 助理教授

主要科研领域与方向

主要运用液态核磁共振技术和计算生物学方法(特别是分子动力学模拟)来研究非编码RNA和固有无序蛋白的结构和动态特性。我们致力于发展新的核磁手段、样品标记方法来研究大的非编码RNA和核糖核酸蛋白复合物的三维结构和构象变化。我们也致力于发展新的计算方法把实验上获得的各种结构数据结合起来对构象高度可变的生物大分子进行建模,并且在此基础上开展基于生物大分子结构和动态的高通量药物筛选。

代表性论文

1. Xue Y, Gracia B, Herschlag D, Russell R, Al-Hashimi HM. (2016) Visualizing formation of an RNA folding intermediate through a fast highly modular secondary structure switch. Nature Communications, 7:11768.

2. Ren A, Xue Y, Peselis A, Serganov A, Al-Hashimi HM, Patel DJ. (2015) Structural and dynamic basis for low-affinity, high-selectivity binding of L-glutamine by the glutamine riboswitch. Cell Reports, 13(9):1800-13.

3. Ma P, Xue Y, Coquelle N, Haller JD, Yuwen T, Ayala I, Mikhailovskii O, Willbold D, Colletier JP, Skrynnikov NR, Schanda P. (2015) Observing the overall rocking motion of a protein in a crystal. Nature Communications, 6:8361.

4. Xue Y, Yuwen T, Zhu F, Skrynnikov NR. (2014) Role of electrostatic interactions in binding of peptides and intrinsically disordered proteins to their folded targets. 1. NMR and MD characterization of the complex between the c-Crk N-SH3 domain and the peptide Sos. Biochemistry, 53 (41): 6473–6495.

5. Xue Y, Ward JM, Yuwen T, Podkorytov IS, Skrynnikov NR. (2012) Microsecond time-scale conformational exchange in proteins: using long molecular dynamics trajectory to simulate NMR relaxation dispersion data. J Am Chem Soc, 134 (5):2555–2562.

6. Xue Y, Skrynnikov NR. (2011) Motion of a disordered polypeptide chain as studied by paramagnetic relaxation enhancements, 15N relaxation, and molecular dynamics simulations: how fast is segmental diffusion in denatured ubiquitin? J Am Chem Soc, 133 (37): 14614–14628.