联系方式

电话:+86-10-62771298(实验室)

邮箱:nyan@tsinghua.edu.cn

颜宁

教授 美国科学院外籍院士 美国艺术与科学院外籍院士

个人履历

1996.09-2000.07 清华大学生物科学与技术系,学士

2000.08-2004.12 美国普林斯顿大学分子生物学系,博士

2005.01-2007.09 美国普林斯顿大学分子生物学系,博士后

2007.10-2017.05 清华大学医学院和生命科学学院,教授、博导

2017.06-2017.10 清华大学生命科学学院,兼职教授、博导

2017.06-2022.11 美国普林斯顿大学分子生物学系,雪莉·蒂尔曼终身讲席教授

2022.12-至今 清华大学生命科学学院,教授、博导

主要科研领域与方向

主要研究方向如下:

1. 与疾病相关重要膜转运蛋白的结构与功能的研究;

2. 电压门控离子通道的结构与工作机理;

3. 胆固醇代谢调控机理。

代表性论文

    1. Xia Yao, Shuai Gao#, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yan# (2022) Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels. Cell, 185(25):4801-4810.

    2. Shuai Gao, Xia Yao, Nieng Yan# (2021) Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature, 596(7870):143-147.

    3. Hongwu Qian#, Xin Zhao, Renhong Yan, Xia Yao, Shuai Gao, Xue Sun, Ximing Du, Hongyuan Yang, Catherine C L Wong, Nieng Yan(2020) Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581(7808):333-338.

    4. Huaizong Shen, Dongliang Liu, Kun Wu, Jianlin Lei, Nieng Yan# (2019) Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Science, 363(6433):1303-1308.

    5. Xiaojing Pan, Zhangqiang Li, Qiang Zhou, Huaizong Shen, Kun Wu, Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan# (2018) Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1. Science, 362(6412): eaau2486.

    6. Huaizong Shen, Qiang Zhou, Xiaojing Pan, Zhangqiang Li, Jianping Wu, Nieng Yan# (2017) Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355(6328): eaal4326.

    7. Wei Peng, Huaizong Shen, Jianping Wu, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S. R. Wayne Chen#Nieng Yan# (2016) Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science, 354(6310): aah5324.

    8. Jianping Wu, Zhen Yan, Zhangqiang Li, Xingyang Qian, Shan Lu, Mengqiu Dong, Qiang Zhou & Nieng Yan# (2016) Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution. Nature, 537(7619): 191–196.

    9. Jianping Wu, Zhen Yan, Zhangqiang Li, Chuangye Yan, Shan Lu, Mengqiu Dong, and Nieng Yan# (2015) Structure of the voltage-gated calcium channel Cav1.1 complex. Science, 350(6267): aad2395.

    10. Dong Deng, Pengcheng Sun, Chuangye Yan, Meng Ke, Xin Jiang, Lei Xiong, Wenlin Ren, Kunio Hirata, Masaki Yamamoto, Shilong Fan & Nieng Yan# (2015) Molecular basis of ligand recognition and transport by glucose transporters. Nature, 526(7573): 391-396.

    11. Zhen Yan, Xiao-chen Bai, Chuangye Yan, Jianping Wu, Zhangqiang Li, Tian Xie, Wei Peng, Chang-cheng Yin, Xueming Li, Sjors H. W. Scheres#, Yigong Shi# & Nieng Yan# (2015) Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517(7532): 50-55.

    12. Dong Deng, Chao Xu, Pengcheng Sun, Jianping Wu, Chuangye Yan, Mingxu Hu & Nieng Yan# (2014) Crystal structure of the human glucose transporter GLUT1. Nature, 510(7503): 121-125.

    13. Linfeng Sun, Xin Zeng, Chuangye Yan, Xiuyun Sun, Xinqi Gong, Yu Rao, and Nieng Yan# (2012) Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature, 490(7420): 361-366.

    14. Xu Zhang, Wenlin Ren, Paul DeCaen, Chuangye Yan, Xiao Tao, Lin Tang, Jingjing Wang, Kazuya Hasegawa, Takashi Kumasaka, Jianhua He, Jiawei Wang, David E. Clapham, and Nieng Yan# (2012) Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature, 486(7401): 130-134.

    15. Shangyu Dang, Linfeng Sun, Feiran Lu, Jiawei Wang#, and Nieng Yan# (2010) Structure of a fucose transporter in an outward-open conformation. Nature, 467(7316), 734-738.