联系方式

电话:62793589

邮箱:Liu_xy@mail.tsinghua.edu.cn

刘翔宇 博士

助理教授

个人履历

2000-2004北京大学 学士

2004-2011北京大学 博士

2008-2010丹麦奥胡斯大学 交流博士生

2011-2013北京大学生命科学学院 博士后

2013-2017清华大学医学院 博士后

2017-2019清华大学医学院 助理研究员

2019-至今清华大学药学院 助理教授

主要科研领域与方向

G蛋白偶联受体(GPCR)是一类具有七次跨膜螺旋的膜蛋白受体,它们感知多种不同胞外信号,调节细胞对环境的反应。其配体包括激素、神经递质、趋化因子等。目前已上市的药物约三分之一靶向GPCR。在过去的十多年,针对GPCR的结构生物学研究取得了巨大的进展,但是对GPCR-G蛋白特异性识别的机理,GPCR偏向性信号传导的机理尚不清楚。本实验室关注与疾病相关的重要GPCR的结构生物学研究,以及基于结构的药物设计。另外,我们也关注新的GPCR药物筛选方法的研发。

代表性论文

1. Xinyu Xu#, Jonas Kaindl#, Mary J. Clark#, Harald Hübner, Kunio Hirata, Roger K. Sunahara*, Peter Gmeiner*, Brian K. Kobilka, Xiangyu Liu*. (2021) Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR. Cell Research. 31, 569-579.

2. Xiangyu Liu#, Jonas Kaindl#, Magdalena Korczynska, Anne Stößel, Daniela Dengler, Markus Stanek, Harald Hübner, Jake Mahoney, Mary J. Clark, Rachel Ann Matt, Xinyu Xu, Kunio Hirata, Brian K. Shoichet, Roger K. Sunahara*, Brian K. Kobilka*, Peter Gmeiner*. (2020) Discovery of an allosteric modulator binding to a conformational hub in the β2 adrenergic receptor. Nature Chemical Biology. 16, 749-755.

3. Xiangyu Liu#, Ali Masoudi#, Alem W. Kahsai#, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, Kunio Hirata, Rishabh K. Simhal, Allison M. Schwalb, Paula K. Rambarat, Seungkirl Ahn, Robert J. Lefkowitz*, Brian Kobilka*. (2019) Mechanism of β2AR regulation by an intracellular positive allosteric modulator.Science, 364 (6447):1283-1287.

4. Xiangyu Liu#*,Xinyu Xu#, Daniel Hilger#, Philipp Aschauer, Johanna K.S. Tiemann, Yang Du, Hongtao Liu, Kunio Hirata, Xiaoou Sun, Ramon Guixà-González, Jesper M. Mathiesen, Peter W. Hildebrand, Brian Kobilka*.(2019) Structural insights into the process of GPCR-G protein complex formation.Cell,177(5):1243-1251.

5. Hongtao Liu#, Josefa Hofmann#, Inbar Fish#, Benjamin Schaake, Katrin Eitel, Amelie Bartuschat, Jonas Kaindl, Hannelore Rampp, Ashutosh Banerjee, Harald Hübner, Mary J. Clark, Sandra G. Vincent , John T. Fisher, Markus R. Heinrich, Kunio Hirata, Xiangyu Liu*, Roger K. Sunahara, Brian K. Shoichet*, Brian K. Kobilka*, Peter Gmeiner*. (2018)Structure-guided development of selective muscarinic M3 acetylcholine receptor antagonists.PNAS.,115(47):12046-12050.

6. Xiangyu Liu#,Seungkirl Ahn#, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, Ali Masoudi, William I. Weis, Ron O. Dror, Xin Chen, Robert J. Lefkowitz*, Brian K. Kobilka*. (2017) Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature, 548:480-484.

7. Yi-He Huang#, Xiangyu Liu#, Xiao-Xia Du, Zheng-Fan Jiang, Xiao-Dong Su. (2012) The Structural Basis for the Sensing and Binding of Cyclic di-GMP by STING. Nature Structural & Molecular Biology,19: 728–730.

8. Pontus Gourdon#, Xiang-Yu Liu#, Tina Skjørringe, J. Preben Morth, Lisbeth Birk Møller*, Bjørn Panyella Pedersen, Poul Nissen*. (2011)Crystal structure of a copper-transporting PIB-type ATPase. Nature, 475: 59-64.