联系方式

电话:+86-10-62782664

邮箱:lixueming@mail.tsinghua.edu.cn

李雪明 博士

副教授
学术指导委员会成员

个人履历

1998-2002北京科技大学材料物理系 学士

2002-2005北京科技大学材料物理与化学系 硕士

2005-2009中国科学院物理研究所 博士

2009-2013加州大学旧金山分校 博士后

2014-2017清华大学生命科学学院 助理教授

2017-2019清华大学生命科学学院 副教授

2019-至今清华大学生命科学学院 副教授(长聘)

主要科研领域与方向

主要从事冷冻电子显微学理论和方法研究,着重于开发和利用最新的电子显微学技术,以提高冷冻电子显微学三维重构的分辨率到原子水平;同时致力于将电子显微学应用到结构生物学研究中去,以解决与结构相关的重要生物学问题。

代表性论文

1. Xinyu Zhang#, Tianfang Zhao#, Jian Chen, Yuan Shen,Xueming Li*.(2022) Epicker is an exemplar-based continual learning approach for knowledge accumulation in cryoEM particle picking.Nature Communication, 2022.13(1):2468

2. Xuzhong Yang#, Chao Lin#, Xudong Chen#, Shouqin Li#,Xueming Li, Bailong Xiao.(2022) Structure deformation and curvature sensing of PIEZO1 in lipid membranes.Nature, 604(7905);377-383.

3. Meijing Li#, Jianfei Ma#,Xueming Li*, Sen-Fang Sui*, In situ cryo-ET structure of phycobilisome - photosystem II supercomplex from red alga,ELife, 2021, 10, e69635.

4. Mingxu Hu#, Qi Zhang#, Jing Yang*,Xueming Li*,Unit quaternion description of spatial rotations in 3D electron cryo-microscopy,Journal of Structural Biology, 2020, 212, 107601

5. Zhaofeng Yan, Meng Yin, Jianan Chen,Xueming Li*.(2020) Assembly and Substrate Recognition of Curli Biogenesis System.Nature Communication, 2020, 11(1), 241.

6. Li Wang, Heng Zhou, Mingmin Zhang, Wenhao Liu, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei,Xueming Li*, Bailong Xiao*.(2019) Structure and mechanogating of the mammalian tactile channel PIEZO2.Nature, 573:225-229.

7. Zhou H, Luo F, Luo Z, Li D, Liu C,Li X*.(2019) Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules.Anal Chem.,91(17):10996-11003.

8. Li M, Xia X, Tian Y, Jia Q, Liu X, Lu Y, Li M,Li X*, Chen Z*.(2019)Mechanism of DNA translocation underlying chromatin remodelling by Snf2.Nature, 567(7748):409-413.

9. Zhou H, Luo Z,Li X*.(2019)Using focus ion beam to prepare crystal lamella for electron diffraction.J Struct Biol., 205(3):59-64.

10. Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, Wu K, Liu W, Zhang T, Dong MQ, Wang J,Li X*, Xiao B*. (2018) Structure and mechanogating mechanism of the Piezo1 channel.Nature, 554(7693):487-492.

11. Mingxu Hu, Hongkun Yu, Kai Gu, Zhao Wang, Huabin Ruan, Kunpeng Wang, Siyuan Ren, Bing Li, Lin Gan, Shizhen Xu, Guangwen Yang*, Yuan Shen*,Xueming Li*, A particle-filter framework for robust cryoEM 3D reconstruction,Nature Methods, 2018, 15, 1083-1089