联系方式

电话:86-10-627-95823

邮箱:qczhang@mail.tsinghua.edu.cn

个人主页

张强锋 博士

副教授
国家杰出青年基金项目获得者

个人履历

1996-2000中国科学技术大学 学士

2000-2006中国科学技术大学 博士

2006-2011哥伦比亚大学 博士

2011-2012哥伦比亚大学 博士后

2012-2015斯坦福大学医学院 博士后

2015-2018清华大学生命科学学院 助理教授

2015-至今清华大学生命科学学院 副教授

主要科研领域与方向

我们实验室是一个结构生物学、基因组学、机器学习和大数据分析等多学科交叉实验室。我们主要的研究兴趣是发展计算和高通量实验相结合的方法,并应用于新兴的结构系统生物学研究,包括使用高通量深度测序的手段来探测RNA二级结构和计算建模,RNA功能模体(motif)等有效预测或发现方法,蛋白-蛋白、RNA-RNA、以及蛋白-RNA相互作用网络,以及结合结构和网络发展进一步疾病诊断、预后以及发展可能的治疗手段。

代表性论文

1. Meiling Piao, Pan Li, Xiaomin Zeng, Xi-Wen Wang, Lan Kang, Jinsong Zhang, Yifan Wei, Shaojun Zhang, Lei Tang, Jianghui Zhu, Chun Kit Kwok, Xiaoyu Hu#, Qiangfeng Cliff Zhang# (2022) An ultra low-input method for global RNA structure probing uncovers Regnase-1-mediated regulation in macrophages, Fundamental Research 2 (1), 2-13
2. Shaojun Zhang*, Wenze Huang*, Lili Ren*, Xiaohui Ju*, Mingli Gong*, Jian Rao*, Lei Sun, Pan Li, Qiang Ding#, Jianwei Wang#, Qiangfeng Cliff Zhang# (2022) Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2, Cell Research 32 (1), 9-23
3. Lei Sun&, Pan Li&, Xiaohui Ju, Jian Rao, Wenze Huang&, Lili Ren, Shaojun Zhang&, Tuanlin Xiong&, Kui Xu&, Xiaolin Zhou, Mingli Gong, Eric Miska, Qiang Ding*, Jianwei Wang*, Qiangfeng Cliff Zhang*. (2021) In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs, Cell 184 (7), 1865-1883. e20
4. Lei Sun&, Kui Xu&, Wenze Huang&, Yucheng Yang, Lei Tang&, Tuanlin Xiong&, Qiangfeng Cliff Zhang*. (2021) Predicting dynamic cellular protein-RNA interactions using deep learning and in vivo RNA structure, Cell Research 31 (5), 495-516
5. Jing Gong, Kui Xu, Ziyuan Ma, Zhi John Lu, Qiangfeng Cliff Zhang*. (2021) A deep learning method for recovering missing signals in transcriptome-wide RNA structure profiles from probing experiments. Nature Machine Intelligence 3 (11), 995-1006
6. Weng, X, Gong, J, Chen, Y, Wu, T, Wang, F, Yang, S, Yuan, Y, Luo, G, Chen, K, Hu, L, Ma, H, Wang, P, Zhang QC*, Zhou, X*, He C*. (2020)  Keth-seq for transcriptome-wide RNA structure mapping. Nature Chemical Biology. (https://doi.org/10.1038/s41589-019-0459-3)
7. Xiong L, Xu K, Tian K, Shao Y, Tang L, Gao G, Zhang M, Jiang T, Zhang QC.(2019)SCALE method for single-cell ATAC-seq analysis via latent feature extraction. Nat Commun, 10: 4576.
8. L Sun, FM Fazal, P Li, JP Broughton, B Lee, L Tang, W Huang, HY Chang*, Zhang QC*. (2019) RNA structure maps across mammalian cellular compartments. Nat Struct Mol Biol., 26(4):322-330.
9. P Li, Y We, M Me, L Tang, L Sun, W Huang, J Zhou, C Zou, S Zhang, CF Qin, T Jiang, J Dai, X Tan*, Zhang QC*. (2018) Integrative Analysis of Zika Virus Genome RNA Structure Reveals Critical Determinants of Viral Infectivity. Cell host & microbe, 24(6): 875-886.
10. X Qian, J Zhao, PY Yeung, Zhang QC*, CK Kwok*. (2018) Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches. Trends in biochemical sciences,44(1): 33-52.