欧光朔 博士

教授
国家杰出青年基金获得者

主要科研领域与方向

细胞生物学和神经发育。我们以模式动物和哺乳类细胞为对象，综合运用超分辨活体成像、冷冻和常温电镜技术、条件性基因编辑和生化分析等方法，研究细胞骨架和信号分子调控不对称细胞分裂、定向细胞迁移、以及纤毛发生的机理。

代表性论文

1.     Kaiming Xu, Zhiyuan Li, Linfan Mao, Zhengyang Guo, Zhe Chen, Yongping Chai, Chao Xie, Xuerui Yang, Jie Na, Wei Li,  Guangshuo Ou^# (2024). AlphaFold2-guided engineering of split-GFP technology enables labeling of endogenous tubulins across species while preserving function. PLoS Biol. 22(8):e3002615.

2.     Chao Xie, Guanghan Chen, Ming Li, Peng Huang, Zhe Chen, Kexin Lei, Dong Li, Yuhe Wang, Augustine Cleetus, Mohamed Aa Mohamed, Punam Sonar, Wei Feng , Zeynep Ökten, Guangshuo Ou^# (2024). Neurons dispose of hyperactive kinesin into glial cells for clearance. EMBO J. 43(13):2606-2635.

3.     Yongping Chai^#, Dong Li, Weibin Gong, Jingyi Ke, Dianzhe Tian, Zhe Chen, Angel Guo, Zhengyang Guo, Wei Li, Wei Feng^#, Guangshuo Ou^# (2024). A plant flavonol and genetic suppressors rescue a pathogenic mutation associated with kinesin in neurons. Proc Natl Acad Sci U S A. 121(5):e2311936121.

4.     Dongdong Li, Di Chen, Wei Li, Guangshuo Ou^# (2024). Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity. Proc Natl Acad Sci U S A. 121(25):e2321228121.

5.     Zhe Chen, Ming Li, Hao Zhu, Guangshuo Ou^# (2023). Modulation of inner junction proteins contributes to axoneme differentiation. Proc Natl Acad Sci U S A. 120(30):e2303955120. 

6.     Zhiwen Zhu, Dongdong Li, Zeran Jia, Wenhao Zhang, Yuling Chen, Ruixue Zhao, Yan-Ping Zhang, Wen-Hong Zhang, Haiteng Deng, Yinqing Li, Wei Li, Shouhong Guang,  Guangshuo Ou^# (2023).Global histone H2B degradation regulates insulin/IGF signaling-mediated nutrient stress. EMBO J. 42(19):e113328. 

7.     Dou Wu, Jingying Huang, Hao Zhu, Zhe Chen, Yongping Chai, Jingyi Ke, Kexin Lei, Zhao Peng, Ranhao Zhang, Xueming Li , Kaiyao Huang, Wei Li, Chengtian Zhao, Guangshuo Ou^# (2022). Ciliogenesis requires sphingolipid-dependent membrane and axoneme interaction. Proc Natl Acad Sci U S A.  119(31):e2201096119.

8.     Hao Zhu, Meijing Li, Ruixue Zhao, Ming Li, Yongping Chai, Zhiwen Zhu, Yihong Yang, Wei Li, Zhongyun Xie, Xiaomin Li, Kexin Lei, Xueming Li^#, Guangshuo Ou^# (2022). In situ structure of intestinal apical surface reveals nanobristles on microvilli. Proc Natl Acad Sci U S A. 119(24):e2122249119.

9.     Dou Wu, Zi Wang, Jingying Huang, Liang Huang, Songbo Zhang, Ruixue Zhao, Wei Li, Di Chen, Guangshuo Ou^# (2022). An antagonistic pleiotropic gene regulates the reproduction and longevity tradeoff. Proc Natl Acad Sci U S A. 119(18):e2120311119.

10. Dongdong Li, Yufan Liu, Peishan Yi, Zhiwen Zhu, Wei Li, Qiangfeng Cliff Zhang, Jin Billy Li,  Guangshuo Ou^# (2021). RNA editing restricts hyperactive ciliary kinases. Science. 373(6558):984-991.