殷国良 博士

北京市优秀毕业生
中国科学院大学优秀毕业生
中国科学院地奥奖学金
国家奖学金
科兴生命医学优秀研究生奖学金

主要科研领域与方向

基于Cryo-ET的生物大分子原位结构与功能研究

代表性论文

1. Kuanying Li*,Guoliang Yin*, Rong Wang, Yun Zhu#, Fei Sun#. The structure of mammalian sperm axoneme provides insights into motility and disease mechanisms[J]. 2026, Curr Top Dev Biol. 

2. Xueming Meng*, Luan Li*, Cheng Lin*, Yun Zhu*, Yanyan Feng*, Xuehai Zhou, Yujie Tong, Shanshan Wang, Guoliang Yin, Ruimin Liu, Fei Sun#, Xiumin Yan#, Xueliang Zhu#, Yao Cong#. Chaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagell. 2026. Mol Cell.

3. Lan Xia*, Guoliang Yin*, Yu Long, Fei Sun, Bin-Bin Wang#, Yun Zhu#, Su-Ren Chen#. A combination of in situ structure biology and Cfap77-knockout mice to reveal the mechanisms of connecting axonemal A and B tubules[J]. 2025, PLoS Biol.

4. Shuntai Yu*, Guoliang Yin*, Peng Jin, Weilin Zhang, Yingchao Tian, Xiaotong Xu, Tianyu Shao, Yushan Li, Fei Sun, Yun Zhu#, Fengchao Wang#. ANKEF1 is a key component of the axoneme required for sperm motility and male fertility[J]. 2025, eLife. 

5. Yun Zhu#*, Tingting Lin*, Guoliang Yin, Linhua Tai, Lianwan Chen, Jing Ma, Guoning Huang, Binbin Wang, Yi Lu, Zhiyong Zhang, Suren Chen#, Fei Sun#. In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia[J]. 2025, Cell Res. (Cover Story)

6. Xiaoyun Pang*, Yan Zhang*, Minh-Triet Hong*, Jian Li, Jiashu Xu, Kunyou Park, Guoliang Yin, Yaoyu Wang, Edward H. Egelman, Seung-Yeol Park#, Victor W. Hsu#, and Fei Sun#. Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission[J]. 2025, PNAS.

7. Linhua Tai*, Guoliang Yin*, Xiaojun Huang, Yun Zhu#, Fei Sun#. In-cell structural insight into the stability of sperm microtubule doublet[J]. 2023, Cell Discov.

8. Linhua Tai*, Guoliang Yin*, Fei Sun#, Yun Zhu#. Cryo-electron Microscopy Reveals the Structure of the Nuclear Pore Complex[J]. 2023, J. Mol Biol. (Cover Review)

9. Shuoguo Li*, Ziyan Wang*, Xing Jia, Tongxin Niu, Jianguo Zhang, Guoliang Yin, Xiaoyun Zhang, Yun Zhu#, Gang Ji#, Fei Sun#. ELI Trifocal microscope: A precise cryogenic fabrication system to prepare target cryo-lamella of cells for in situ cryo-ET study[J]. 2023. Nat Methods.

10. Guoliang Yin, Wenhao Sun, Xiaoyun Pang, Fei Sun. Application of cryo-electron microscopy in molecular botany research[J]. 2022, Biotechnol Bull.

11. Miao-Miao Zhao*, Yun Zhu*, Li Zhang*, Gongxun Zhong*, Linhua Tai, Shuo Liu, Guoliang Yin, Weijin Huang, Changfa Fan, Lei Shuai, Zhiyuan Wen, Chong Wan, Xijun He, Zhigao Bu#, Youchun Wang#, Fei Sun# and Jin-Kui Yang#. Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies[J]. 2022, Cell Discov.

12. Linhua Tai*, Guoliang Zhu*, Minnan Yang*, Lei Cao, Xiaorui Xing, Guoliang Yin, Chun Chan, Chengfeng Qin, Zihe Rao, Xiangxi Wang#, Fei Sun#, Yun Zhu#. Nanometer resolution in situ structure of the SARS-CoV-2 postfusion spike protein[J]. 2021, PNAS.

13. He Ren*, Yun Zhu*, Linhua Tai*, Chun Chan*, Qun Zhao*, Jiashu Xu, Xiangyang Wang, Xinyao Ma, Lili Zhao, Xiaojun Huang, Guoliang Yin, Mingkang Jia, Xiaohong Zhu, Yuxin An, Gan Zhao, Chuangxiong Huang, Lihua Zhang#, Fan Jun#, Fei Sun# and Chuanmao Zhang#.Determining the architecture of nuclear ring of Xenopus laevis nuclear pore complex using integrated approaches. 2021, BioRxiv.