靳雪芹 博士

北京大学优秀毕业生
北京市优秀毕业生

主要科研领域与方向

利用结构生物学、结构药理学、电生理学等研究电压依赖钠/钙离子通道的工作机制；靶向离子通道的药物研发；生理及病理过程中离子通道的功能及机制研究等。

代表性论文

1. Jian Huang#; Xiao Fan#; Xueqin Jin#; Chen Lyu; Qinmeng Guo; Tao Liu; Jiaofeng Chen; Amaël Davakan; Philippe Lory; Nieng Yan; Structural basis for human Cav3.2 inhibition by selective antagonists, Cell Research, 2024, 34(34): 440-450 (#co-first)

2. Xueqin Jin#*; Jian Huang#; Huan Wang#; Kan Wang; Nieng Yan*; A versatile residue numbering scheme for Nav and Cav channels, Cell Chemical Biology, 2024, 31 (#co-first, *co-corresponding)

3. Wang H, Huang J, Zang J, Jin X*, Yan N*. Drug discovery targeting Na_v1.8: Structural insights and therapeutic potential. Curr Opin Chem Biol. 2024 Dec; 83:102538. doi: 10.1016/j.cbpa.2024.102538. Epub 2024 Oct 17. Erratum in: Curr Opin Chem Biol. 2025 Feb; 84: 102546. doi: 10.1016/j.cbpa.2024.102546. PMID: 39418835. (*co-corresponding)

4. Li Z#, Wu Q#, Huang G#, Jin X#, Li J, Pan X, Yan N. Dissection of the structure-function relationship of Na_v channels. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9): e2322899121. doi: 10.1073/pnas.2322899121. Epub 2024 Feb 21. PMID: 38381792; PMCID: PMC10907234.

5. Qiurong Wu#; Jian Huang#; Xiao Fan#; Kan Wang#; Xueqin Jin#; Gaoxingyu Huang; Jiaao Li; Xiaojing Pan; Nieng Yan; Structural mapping of Nav1.7 antagonists, Nature Communications, 2023,14

6. Huang X#, Jin X#, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N. Structural basis for high-voltage activation and subtype-specific inhibition of human Na_v1.8. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30): e2208211119. doi: 10.1073/pnas.2208211119. Epub 2022 Jul 19. PMID: 35858452; PMCID: PMC9335304.

7. Pan X#, Li Z#, Jin X#, Zhao Y#, Huang G#, Huang X, Shen Z, Cao Y, Dong M, Lei J, Yan N. Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021 Mar16;118(11):e2100066118. doi: 10.1073/pnas.2100066118. PMID: 33712547.

8. Li Z#, Jin X#, Wu T#, Huang G#, Wu K, Lei J, Pan X, Yan N. Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine. Angew Chem Int Ed Engl. 2021 Mar 8. doi: 10.1002/anie.202102196. Epub

ahead of print. PMID: 33684260.

9. Ma Y#, Xie H#, Du X#, Wang L#, Jin X#, Zhang Q#, Han Y, Sun S, Wang L, Li X, Zhang C, Wang M, Li C, Xu J, Huang Z, Wang X, Chai Z, Deng H. In vivo chemical reprogramming of astrocytes into neurons. Cell Discov. 2021 Mar 2;7(1):12. doi:10.1038/s41421-021-00243-8. PMID: 33649311; PMCID: PMC7921425.

10. Chi X#, Jin X#, Chen Y#, Lu X#, Tu X, Li X, Zhang Y, Lei J, Huang J, Huang Z, Zhou Q, Pan X. Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence. Cell Discov. 2020 Aug 10; 6:55. doi: 10.1038/s41421-020-00193-7. PMID: 32818062; PMCID: PMC7417587.

11. Jin X, Chen Q, Song Y, Zheng J, Xiao K, Shao S, Fu Z, Yi M, Yang Y, Huang Z. Dopamine D2 receptors regulate the action potential threshold by modulating T-type calcium channels in stellate cells of the medial entorhinal cortex. J Physiol. 2019Jul;597(13):3363-3387. doi: 10.1113/JP277976. Epub 2019 May 28. PMID: 31049961.

12. Huang J, Fan X, Jin X, Jo S, Zhang HB, Fujita A, Bean BP, Yan N. Cannabidiol inhibits Na_v channels through two distinct binding sites. Nat Commun. 2023 Jun 17;14(1):3613. doi: 10.1038/s41467-023-39307-6. PMID: 37330538; PMCID: PMC10276812.

13. Li Z, Jin X, Wu T, Zhao X, Wang W, Lei J, Pan X, Yan N. Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2100069118. doi:10.1073/pnas.2100069118. PMID: 33712541.

14. Xiao K#, Sun Z#, Jin X, Ma W, Song Y, Lai S, Chen Q, Fan M, Zhang J, Yue W, Huang

Z. ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice. J Physiol. 2018 Oct;596(19):4729-4752. doi:

10.1113/JP275970. Epub 2018 Sep 7. PMID: 30016551; PMCID: PMC6166062.

15. Liu Y#, Li M#, Fan M, Song Y, Yu H, Zhi X, Xiao K, Lai S, Zhang J, Jin X, Shang Y, Liang J, Huang Z. Chromodomain Y-like Protein-Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors. Biol Psychiatry. 2019 Apr 15;85(8):635-649. doi: 10.1016/j.biopsych.2018.11.025. Epub 2018 Dec 5. PMID: 30665597.

16. Li X#, Liu D#, Ma Y#, Du X#, Jing J#, Wang L, Xie B, Sun D, Sun S, Jin X, Zhang X, Zhao T, Guan J, Yi Z, Lai W, Zheng P, Huang Z, Chang Y, Chai Z, Xu J, Deng H. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Cell Stem Cell. 2017 Aug 3;21(2):264-273.e7. doi: 10.1016/j.stem.2017.05.019. Epub 2017 Jun 22. PMID:

28648365.