裴高峰 博士

2021 国家奖学金
2022 清华大学综合奖学金（一等）
2023 清华大学CLS博士后基金杰出奖
2023 北京生物结构前沿研究中心卓越学者

主要科研领域与方向

生物大分子相分离

代表性论文

1. Jinnan He#, Xiangru Huo#, Gaofeng Pei#, Zeran Jia#, Yiming Yan, Jiawei Yu, Haozhi Qu, Yunxin Xie, Junsong Yuan, Yuan Zheng, Yanyan Hu, Minglei Shi, Kaiqiang You, Tingting Li, Tianhua Ma, Michael Q. Zhang, Sheng Ding, Pilong Li*, and Yinqing Li*. Dual-role transcription factors stabilize intermediate expression levels. CELL, 2024, 187, 2746-2766. (#Co-first author)

2. Gaofeng Pei#, Heankel Lyons#, Pilong Li*, and Benjamin R. Sabari*. Formation and regulation of transcriptional condensates and their roles in physiology and disease. Nature Reviews Molecular Cell Biology, 2024. (#Co-first author. Invited review, in revision)

3. Gaofeng Pei#, Weifan Xu#, Jun Lan, Xinquan Wang, and Pilong Li*. CEBIT Screening for Inhibitors of the Interaction between SARS-CoV-2 Spike and ACE2. Fundamental Research, 2022, 2, 4: 562-569. (#Co-first author)

4. Gaofeng Pei#, Min Zhou#, Weifan Xu, Jing Wang, and Pilong Li*. Phase Separation-Based Biochemical Assays for Biomolecular Interactions. Methods in Molecular Biology. 2023, 2563: 225-236. (#Co-first author)

5. Yifei Gao#, Gaofeng Pei#, Dongxue Li#, Ru Li, Yanqiu Shao, Qiangfeng Cliff Zhang, and Pilong Li*. Multivalent m6A motifs promote phase separation of YTHDF proteins. Cell Research, 2019, 29: 767-769 (#Co-first author)

6. Jiaojiao Wang#, Gaofeng Pei#, Yupei Wang#, Dewei Wu#, Xiaokang Liu, Gaoming Li, Jianfang He, Xiaolin Zhang, Xiaoyi Shan*, Pilong Li*, Daoxin Xie*. Phase separation of nuclear pore complex facilitates selective nuclear transport to regulate plant defense against pathogen and pest invasion. Molecular Plant, 2023, 6: 1016-1030. (#Co-first author)

7. Weifan Xu#, Gaofeng Pei#, Hongrui Liu#, Xiaohui Ju, Jing Wang, Qiang Ding, and Pilong Li*. Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome. Cell Reports, 2021, 36(5): 109482. (#Co-first author)

8. Yuan Wang#, Chunyu Yu#, Gaofeng Pei#, Wen Jia, Tingting Li*, Pilong Li*. Prevalent aberrant condensates of onco-fusion transcription factors and their dissolution as potential cancer therapy. Nature Chemical Biology. 2023, 19(10): 1223-1234. (#Co-first author)

9. Songhao Zhang#, Gaofeng Pei#, Boya Li#, Pilong Li*, and Yi Lin*. Abnormal phase separation of biomacromolecule in human diseases. Acta Biochimica et Biophysica Sinica. 2023, 55(7): 1133-1152 (#Co-first author)

10. Mingrui Ding#, Weifan Xu#, Gaofeng Pei#, and Pilong Li*. Long way up: rethink diseases in light of phase separation and phase transition. Protein & Cell, 2024, pwad057