邮箱:guangshuoou@mail.tsinghua.edu.cn
教授
国家杰出青年基金获得者
1994-1998 中国农业大学生物学院 学士
1998-2001 中国农业大学生物学院 硕士
2001-2006 加利福尼亚州大学戴维斯分校 博士
2007-2011 加利福尼亚州大学旧金山分校/霍华德休斯医学研究院 (HHMI) 博士后
2011-2013 中国科学院生物物理研究所 研究员
2013-至今 清华大学生命科学学院 教授
细胞生物学和神经发育。我们以模式动物和哺乳类细胞为对象,综合运用超分辨活体成像、冷冻和常温电镜技术、条件性基因编辑和生化分析等方法,研究细胞骨架和信号分子调控不对称细胞分裂、定向细胞迁移、以及纤毛发生的机理。
1. Kaiming Xu, Zhiyuan Li, Linfan Mao, Zhengyang Guo, Zhe Chen, Yongping Chai, Chao Xie, Xuerui Yang, Jie Na, Wei Li, Guangshuo OuAlphaFold2-guided engineering of split-GFP technology enables labeling of endogenous tubulins across species while preserving function. PLoS Biol. 22(8):e3002615.
2. Chao Xie, Guanghan Chen, Ming Li, Peng Huang, Zhe Chen, Kexin Lei, Dong Li, Yuhe Wang, Augustine Cleetus, Mohamed Aa Mohamed, Punam Sonar, Wei Feng, Zeynep Ökten, Guangshuo Ou Neurons dispose of hyperactive kinesin into glial cells for clearance. EMBO J. 43(13):2606-2635.
3. Yongping Chai#, Dong Li, Weibin Gong, Jingyi Ke, Dianzhe Tian, Zhe Chen, Angel Guo, Zhengyang Guo, Wei Li, Wei Feng#, Guangshuo OuA plant flavonol and genetic suppressors rescue a pathogenic mutation associated with kinesin in neurons. Proc Natl Acad Sci U S A. 121(5):e2311936121.
4. Dongdong Li, Di Chen, Wei Li, Guangshuo Ou Inhibition of a cyclic nucleotide-gated channel on neuronal cilia activates unfolded protein response in intestinal cells to promote longevity. Proc Natl Acad Sci U S A. 121(25):e2321228121.
5. Zhe Chen, Ming Li, Hao Zhu, Guangshuo Ou Modulation of inner junction proteins contributes to axoneme differentiation. Proc Natl Acad Sci U S A. 120(30):e2303955120.
6. Zhiwen Zhu, Dongdong Li, Zeran Jia, Wenhao Zhang, Yuling Chen, Ruixue Zhao, Yan-Ping Zhang, Wen-Hong Zhang, Haiteng Deng, Yinqing Li, Wei Li, Shouhong Guang, Guangshuo Ou EMBO J. 42(19):e113328.
7. Dou Wu, Jingying Huang, Hao Zhu, Zhe Chen, Yongping Chai, Jingyi Ke, Kexin Lei, Zhao Peng, Ranhao Zhang, Xueming Li, Kaiyao Huang, Wei Li, Chengtian Zhao,Guangshuo Ou Proc Natl Acad Sci U S A. 119(31):e2201096119.
8. Hao Zhu, Meijing Li, Ruixue Zhao, Ming Li, Yongping Chai, Zhiwen Zhu, Yihong Yang, Wei Li, Zhongyun Xie, Xiaomin Li, Kexin Lei, Xueming Li,Guangshuo Ou In situ structure of intestinal apical surface reveals nanobristles on microvilli. Proc Natl Acad Sci U S A. 119(24):e2122249119.
9. Dou Wu, Zi Wang, Jingying Huang, Liang Huang, Songbo Zhang, Ruixue Zhao, Wei Li, Di Chen, Guangshuo OuAn antagonistic pleiotropic gene regulates the reproduction and longevity tradeoff. Proc Natl Acad Sci U S A. 119(18):e2120311119.
10. Dongdong Li, Yufan Liu, Peishan Yi, Zhiwen Zhu, Wei Li, Qiangfeng Cliff Zhang, Jin Billy Li, Guangshuo Ou RNA editing restricts hyperactive ciliary kinases. Science. 373(6558):984-991.