时松海 博士

教授
清华大学生命科学学院院长
清华大学IDG-麦戈文脑科学研究院院长
北京市卓越青年科学家

主要科研领域与方向

大脑神经系统是如何组装的以及如何调控动物的行为和认知一直是神经科学的研究热点和终极目标之一。我们运用神经生物学（如电生理和成像）、遗传学、分子、细胞和发育生物学等方法研究大脑的有序组装和有效运行机制，集中于活体神经干细胞的调控、神经细胞的产生分化、神经环路的精准组装和运行以及动物行为的神经基础，同时致力于与神经发育相关的重大疾病如小脑症和自闭症的致病机制研究。

代表性论文

1. Shen, Z., Lin, Y., Yang, J., Jorg, D.J., Peng, Y., Zhang, X., Xu, Y., Hernandez, L., Ma, J., Simons, B.D., and Shi, S.-H*. (2021) Distinct Progenitor Behavior Underlying Neocortical Gliogenesis Related to Tumorigenesis. Cell Rep. 34(11): 108853. ( PMID: 33730566)

2. Shao W, Yang J, He M, Yu X.-Y., Lee, C.H., Yang, Z., Joyner, A.L., Anderson, K. V., Zhang, J., Tsou, M.B., Shi, H., and Shi, S.-H. (2020) Centrosome anchoring regulates progenitor properties and cortical formation. Nature, 580:106-112.

3. Ren, S.Q., Li, Z., Lin, S., Bergami, M., and Shi, S.-H. (2019) Precise long-range microcircuit-to-microcircuit communication connects the frontal and sensory cortices in the mammalian brain. Neuron,104:1-17.

4. Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K., and Shi, S.-H. (2017) Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus. Nat. Neurosci, 20:516-528.

5. He, S., Li, Z., Ge, S., Yu, Y.-C., and Shi, S.-H. (2015) Inside-out Radial Migration Facilitates Lineage-dependent Microcircuit Assembly in the Neocortex. Neuron, 86:1159-1166.

6. Xu, H.-T., Han Z., Gao, P., He, S., Li, Z., Shi, W., Kordish, O., Shao, W., Brown, K.N., Huang, K., and Shi. S-H. (2014) Lineage-dependent structural and functional organization of the hippocampus. Cell, 157:1552-1564.

7. Gao, P., Postiglione Pia, M., Krieger, T.G., Hernandez, L., T., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., Kodish, O., Huang, K., Simons, B.D., Luo, L., Hippenmeyer, S., and Shi, S.-H. (2014) Deterministic progenitor behavior and unitary production of neurons in the neocortex. Cell,159:775-788.

8. Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K.N., Yao, X.H., Ma, J., Gao, K.P., Sosinsky, G.E., Huang, K., and Shi, S.-H. (2012) Preferential electric coupling regulates neocortical lineage-dependent microcircuit assembly. Nature, 486:113-7.

9. Brown, K.N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Ding, L., Zhang, X.-J., Cruz, A. L., Saur, D., Anderson, S.A., Huang, K., and Shi, S.-H. (2011) Clonal Production and Organization of Inhibitory Interneurons in the Neocortex. Science, 334: 480-486.

10. Wang, X., Tsai, J.-W., Imai, J.H., Lin, W.-N., Valle, R.B., and Shi, S.-H. (2009) Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature, 461: 947-955.