邮箱：li-dong@tsinghua.edu.cn
科学探索奖
2002-2006 浙江大学光电信息工程学系 学士
2006-2011 香港科技大学电子与计算机工程学系 博士
2011-2015 霍华德∙休斯医学研究所 博士后
2015-2024 中国科学院生物物理研究所 研究员
2024-至今 清华大学生命科学学院 教授
李栋课题组致力于光学显微成像技术的研制与应用工作，先后开发了:（1）条纹激活非线性结构光显微镜; （2）掠入射结构光超分辨显微镜;（3）合理化深度学习超分辨成像框架等技术方法，并利用这些新型成像技术开展细胞与发育生物学研究，可在高时空分辨率下连续捕捉细胞内生物过程的动态分子事件，提供与测序、生化、质谱等方法相互补的时空动态信息。
1. Qiao C#, Chen H#, Wang R#, Jiang T, Wang Y, Li D*. Deep learning-based optical aberration estimation enables offline digital adaptive optics and super-resolution imaging. Photonics Research, 2024 Mar; 12(3):474-484. Cover article.
2. Qiao C#, Zeng Y#, Meng Q#, Chen X#, Chen H, Jiang T, Wei R, Guo J, Fu W, Lu H, Li D, Wang Y, Qiao H, Wu J, Li D*, Dai Q*. Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy. Nature Communications, 2024 May; 15(1):4180.
3. Qiao C#, Li D#, Liu Y#, Zhang S#, Liu K, Liu C, Guo Y, Jiang T, Fang C, Li N, Zeng Y, He K, Zhu X, Lippincott-Schwartz J*, Dai Q*, Li D*. Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes. Nature Biotechnology, 2023 Mar; 41(3):367-377. Cover article.
4. Gong B#, Guo Y#, Ding S, Liu X, Meng A, Li D*, Jia S*, A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. Nature Cell Biology, 2021 Jul; 23(7):782-795.
5. Xu G#, Liu C#, Zhou S#, Li Q, Feng Y, Sun P, Feng H, Gao Y, Zhu J, Luo X, Zhan Q, Liu S, Zhu S, Deng H*, Li D*, Gao P*. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Molecular Cell, 2021 Jul 1;81(13):2823-2837.
6. Li D#, Colin-York H#, Barbieri L#, Javanmardi Y#, Guo Y, Korobchevskaya K, Moeendarbary E*, Li D*, Fritzsche M*. Astigmatic traction force microscopy (aTFM). Nature Communications, 2021 Apr 12; 12(1):2168.
7. Qiao C#, Li D#, Guo Y#, Liu C#, Jiang T, Dai Q*, Li D*. Evaluation and development of deep neural networks for image super-resolution in optical microscopy. Nature Methods, 2021 Feb;18(2):194-202.
8. Wang X#*, Liu C#, Zhang S#, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D*. N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles. Developmental Cell, 2021 Mar 8;56(5):702-715.
9. Qin J, Guo Y, Xue B, Shi P, Chen Y, Su Q, Hao H, Zhao S, Wu C, Yu L, Li D*, Sun Y*. ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. Nature Communications, 2020 Sep 8;11(1):4471.
10. Guo Y #, Li D#, Zhang S, Yang Y, Liu JJ, Wang X, Liu C, Milkie DE, Moore RP, Tulu US, Kiehart DP, Hu J, Lippincott-Schwartz J*, Betzig E*, Li D*.Visualizing intracellular organelle and cytoskeletal interactions at nanoscale resolution on millisecond timescales. Cell, 2018 Nov 15;175(5):1430-1442.
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