电话:+86-10-62786823
邮箱:zhucheng_chen@mail.tsinghua.edu.cn
教授
1994-1998南开大学 学士
1998-2001北京大学 硕士
2001-2003纽约大学 硕士
2003-2008康奈尔大学 博士
2008-2008纪念斯隆-凯特琳癌症中心 博士后
2008-2011德克萨斯大学西南医学中心 博士后
2011-2017清华大学生命科学学院 长聘系列副教授
2017-2020清华大学生命科学学院 长聘副教授
2020-至今清华大学生命科学学院 教授
利用晶体学和电子显微镜学等多种生物物理手段研究重要蛋白质分子机器的工作机理, 尤其是染色质重塑的机理。
2. Wang L#, Chen K#, Chen Z *. (2021) Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nature Comm., 12 (1):4058.
3. Chen M#, Pan H#, Sun L#, Shi P#, Zhang Y, Li L, Huang Y, Chen J, Jiang P, Fang X, Wu C, Chen Z *. (2020) Structure and regulation of human epithelial cell transforming 2 protein. PNAS, 117(2):1027-1035.
4. Ye Y#, Wu H#, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR*, Gao N*, Chen Z *. (2019 ) Structure of the RSC complex bound to the nucleosome. Science, 66(6467):838-843.
5. Yan L#, Wu H#, Li X, Gao N*, Chen Z *. (2019) Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat. Struct. Mol. Biol., 26(4):258-266.
6. Li M#Xia X#, Tian Y#, Jia Q#, Liu X#, Lu Y, Li M*, Li X*, Chen Z *. (2019) Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567(7748):409-413.
7. Liu X#, Li M#, Xia X#, Li X*, Chen Z *. (2017) Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure Nature,544 (7651):440-445.
8. Yan L#, Wang L#, Tian Y, Xia X, Chen Z *. (2016) Structure and regulation of the chromatin remodeller ISWI. Nature,540(7633):466-469.
9. Xu P#, Li C#, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z *. (2016) The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. Mol. Cell., 63 (6):965-75.
10. Xia X#, Liu X#, Li T, Fang, X, Chen Z *. (2016) Structure of chromatin remodeller Swi2/Snf2 in the resting state. Nat. Struct. Mol. Biol., 23(8):722-9