薛毅 博士

助理教授

主要科研领域与方向

我们主要运用液态核磁共振技术和计算生物学方法（特别是分子动力学模拟）来研究非编码RNA和固有无序蛋白的结构和动态特性。我们致力于发展新的核磁手段、样品标记方法来研究大的非编码RNA和核糖核酸蛋白复合物的三维结构和构象变化。我们也致力于发展新的计算方法把实验上获得的各种结构数据结合起来对构象高度可变的生物大分子进行建模，并且在此基础上开展基于生物大分子结构和动态的高通量药物筛选。

代表性论文

1.   Ning Liu, Oleg Mikhailovskii, Nikolai Skrynnikov, and Yi Xue^# (2023). Simulating diffraction photographs based on molecular dynamics trajectories of a protein crystal: a new option to examine structure-solving strategies in protein crystallography, IUCrJ, 10(1): 16-26.

2.   Wei He, Xinming Li, Hongjuan Xue, Yuanyuan Yang, Jun Mencius, Ling Bai, Jiayin Zhang, Jianhe Xu, Bin Wu^#, Yi Xue^#, and Shu Quan^# (2022). Insights into the client protein release mechanism of the ATP-independent chaperone Spy, Nature Communications, 13(1): 2818.

3.   Ge Han, and Yi Xue^# (2022). Rational design of hairpin RNA excited states reveals multi-step transitions, Nature Communications, 13(1): 1523.

4.   Jingyi Cao, and Yi Xue^# (2021). Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures, Nucleic Acids Research, 49(8): 4294-4307.

5.   Yanjiao Wang, Ge Han, Xiuying Jiang, Tairan Yuwen, and Yi Xue^# (2021). Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states, Nature Communications, 12(1): 1595.