Cyclic Peptide DataBank (CPDB)
Browse and visualize 3D structures of polypeptides
Browse and visualize 3D structures of polypeptides
Welcome to the Cyclic Peptide DataBank (CPDB), a comprehensive knowledge base focused on the three-dimensional structures of cyclic peptides containing disulfide bonds.
Cyclic peptides, especially those with disulfide bonds, are at the forefront of biological research and drug discovery due to their unique stability, high target affinity, and potent biological activity. Our database aims to consolidate this vital structural information, which is often scattered across various sources, into a single, accessible platform.
Our database is built upon high-quality experimental data. The majority of structures are determined by X-ray diffraction, ensuring atomic-level precision, while a significant portion of our entries feature the key disulfide bonds characteristic of the peptides we focus on.
Data quality is paramount, with a large number of structures boasting high resolution. These peptides originate from a diverse range of species, many of which are known for producing potent bioactive compounds.
We believe that CPDB is not just a data repository but a catalyst for stimulating innovation and accelerating research.
Whether you are dedicated to exploring new natural products or designing the next generation of peptide drugs, this database will provide you with valuable structural information support to push the boundaries of science.
The collected peptides vary in size, fitting the typical profile of functional cyclic peptides. The timeline of structure releases showcases the steady growth and expanding interest in this fascinating class of molecules.