Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	1LPH Go to RCSB ➚
Title	LYS(B28)PRO(B29)-HUMAN INSULIN
Method	X-RAY DIFFRACTION
Resolution	2.30 Å
Release Date	1996-06-20
Authors	Ciszak, E.; Beals, J.M.; Frank, B.H.; Baker, J.C.; Carter, N.D.; Smith, G.D.
Source Organism	Homo sapiens
Keywords	INSULIN ANALOGUE, HORMONE, GLUCOSE METABOLISM
Molecular Weight	11.90 kDa
Entity Count	Protein: 2, Nucleic Acid: 0, NA Hybrid: 0
Space Group	H 3
Cell Parameters	a=79.62 Å, b=79.62 Å, c=37.78 Å, α=90.00°, β=90.00°, γ=120.00°
Disulfide Bond	A6-A11;C6-C11
Other Links	Yes
Peptide Chains	A, B, C, D
Peptide Lengths	30, 21

1	FVNQHLCGSH LVEALYLVCG ERGFFYTKPT

1	GIVEQCCTSI CSLYQLENYC N

Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin.

Ciszak, E., Beals, J.M., Frank, B.H., Baker, J.C., Carter, N.D., Smith, G.D.

Structure, 1995

The Structure of a Complex of Hexameric Insulin and 4'-Hydroxyacetanilide

Smith, G.D., Ciszak, E.

Proc Natl Acad Sci U S A, 1994

Crystallographic Evidence for Dual Coordination Around Zinc in the T3R3 Human Insulin Hexamer

Ciszak, E., Smith, G.D.

Biochemistry, 1994

Structural Stability in the 4-Zinc Human Insulin Hexamer

Smith, G.D., Swenson, D.C., Dodson, E.J., Dodson, G.G., Reynolds, C.D.

Proc Natl Acad Sci U S A, 1984

ID	Name	Formula	Molecular Weight
ZN	ZINC ION	Zn	65.409
IPH	PHENOL	C6 H6 O	94.111
CL	CHLORIDE ION	Cl	35.453

Assembly ID: 1

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 2-mer

Stoichiometry: A1, B1

Assembly ID: 2

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 2-mer

Stoichiometry: A1, B1

Assembly ID: 3