Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	1M63 Go to RCSB ➚
Title	Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
Method	X-RAY DIFFRACTION
Resolution	2.80 Å
R-factors	R-work: 0.260, R-free: 0.322
Release Date	2002-09-25
Authors	Huai, Q.; Kim, H.-Y.; Liu, Y.; Zhao, Y.; Mondragon, A.; Liu, J.O.; Ke, H.
Source Organism	HOMO SAPIENS, TOLYPOCLADIUM INFLATUM
Expression Host	Escherichia coli BL21
Gene Names	CNA ALPHA, CNB
Keywords	HYDROLASE-ISOMERASE-IMMUNOSUPPRESSANT COMPLEX, IMMUNOPHILIN, CALCINEURIN, CYCLOSPORIN A, IMMUNOSUPPRESSANT, CYCLOPHILIN
EC Number	3.1.3.16, 5.2.1.8
Molecular Weight	163.21 kDa
Entity Count	Protein: 4, Nucleic Acid: 0, NA Hybrid: 0
Space Group	P 41 21 2
Cell Parameters	a=108.66 Å, b=108.66 Å, c=316.59 Å, α=90.00°, β=90.00°, γ=90.00°
Other Links	Yes
Peptide Chains	D, H
Protein Chains	A, B, C, E, F, G
Peptide Lengths	11
Protein Lengths	372, 169, 165

1	MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV
61	ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV
121	DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD
181	AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG
241	NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
301	SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
361	VTEMLVNVLN IC

1	GNEASYPLEM CSHFDADEIK RLGKRFKKLD LDNSGSLSVE EFMSLPELQQ NPLVQRVIDI
61	FDTDGNGEVD FKEFIEGVSQ FSVKGDKEQK LRFAFRIYDM DKDGYISNGE LFQVLKMMVG
121	NNLKDTQLQQ IVDKTIINAD KDGDGRISFE EFCAVVGGLD IHKKMVVDV

1	MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF
61	MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE
121	WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE

1	ALLVTAGLVL A

Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes

Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J.O., Ke, H.

Proc Natl Acad Sci U S A, 2002

ID	Name	Formula	Molecular Weight
ZN	ZINC ION	Zn	65.409
FE	FE (III) ION	Fe	55.845
CA	CALCIUM ION	Ca	40.078

Assembly ID: 1

Details: software_defined_assembly

Oligomeric State: Hetero 8-mer

Stoichiometry: A2, B2, C2, D2