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Cyclic Peptide DataBank (CPDB)

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3E4H - Cyclic Peptide Structure

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Summary

PDB ID3E4H Go to RCSB ➚
TitleCrystal structure of the cyclotide varv F
MethodX-RAY DIFFRACTION
Resolution1.80 Å
R-factorsR-work: 0.224, R-free: 0.244
Release Date2009-02-10
AuthorsHu, S.H.
Source OrganismViola arvensis
Keywordscyclotide, circular proteins, cystine knot, cyclization, PLANT PROTEIN, Knottin, Plant defense
Molecular Weight2.98 kDa
Entity CountProtein: 1, Nucleic Acid: 0, NA Hybrid: 0
Space GroupI 41 3 2
Cell Parametersa=84.08 Å, b=84.08 Å, c=84.08 Å, α=90.00°, β=90.00°, γ=90.00°
Disulfide BondA1-A15;A5-A17;A10-A22
Other LinksYes
Peptide ChainsA
Peptide Lengths29

Sequence Information

Chain: A - Varv peptide F,Varv peptide F (Length: 29)

1CGETCTLGTC YTAGCSCSWP VCTRNGVPI

References

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

Wang, C.K., Hu, S.H., Martin, J.L., Hajdu, J., Bohlin, L., Claeson, P., Rosengren, K.J., Tang, J., Tan, N.H., Craik, D.J.

J Biological Chem, 2009

PubMed: 19211551 | DOI: 10.1074/jbc.M900021200

Biological Assemblies

Assembly ID: 1

Details: author_defined_assembly

Oligomeric State: Monomer

Stoichiometry: A1

Assembly ID: 2

Details: software_defined_assembly

Oligomeric State: Homo 6-mer

Stoichiometry: A6

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