Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	3M17 Go to RCSB ➚
Title	Crystal structure of human FcRn with a monomeric peptide inhibitor
Method	X-RAY DIFFRACTION
Resolution	2.60 Å
R-factors	R-work: 0.261, R-free: 0.325
Release Date	2010-06-16
Authors	Mezo, A.R.; Sridhar, V.; Badger, J.; Sakorafas, P.; Nienaber, V.
Source Organism	Homo sapiens
Expression Host	Cricetinae
Gene Names	B2M, CDABP0092, FCGRT, FCRN, HDCMA22P
Keywords	IMMUNOGLOBULIN BINDING PROTEIN, Cell membrane, Disulfide bond, Glycoprotein, IgG-binding protein, Immunoglobulin domain, Membrane, Receptor, Transmembrane, Amyloid, Amyloidosis, Disease mutation, Glycation, Immune response, MHC I, Pyrrolidone carboxylic acid, Secreted, IMMUNE SYSTEM-INHIBITOR complex
Molecular Weight	172.03 kDa
Entity Count	Protein: 3, Nucleic Acid: 0, NA Hybrid: 0
Space Group	C 2 2 21
Cell Parameters	a=114.32 Å, b=118.30 Å, c=248.33 Å, α=90.00°, β=90.00°, γ=90.00°
Disulfide Bond	I3-I13;J3-J13;K3-K13;L3-L13
Other Links	Yes
Peptide Chains	I, J, K, L
Protein Chains	A, B, C, D, E, F, G, H
Peptide Lengths	15
Protein Lengths	267, 99

1	AESHLSLLYH LTAVSSPAPG TPAFWVSGWL GPQQYLSYNS LRGEAEPCGA WVWENQVSWY
61	WEKETTDLRI KEKLFLEAFK ALGGKGPYTL QGLLGCELGP DNTSVPTAKF ALNGEEFMNF
121	DLKQGTWGGD WPEALAISQR WQQQDKAANK ELTFLLFSCP HRLREHLERG RGNLEWKEPP
181	SMRLKARPSS PGFSVLTCSA FSFYPPELQL RFLRNGLAAG TGQGDFGPNS DGSFHASSSL
241	TVKSGDEHHY CCIVQHAGLA QPLRVEL

1	IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW
61	SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM

1	XRFXTGHFGG LYPCX

X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.

Mezo, A.R., Sridhar, V., Badger, J., Sakorafas, P., Nienaber, V.

J Biological Chem, 2010