Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	4LBF Go to RCSB ➚
Title	Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant
Method	X-RAY DIFFRACTION
Resolution	1.70 Å
R-factors	R-work: 0.185, R-free: 0.231
Release Date	2013-11-27
Authors	Tolbert, W.D.; Wu, X.; Pazgier, M.
Source Organism	Homo sapiens
Keywords	ANTIMICROBIAL PEPTIDE, HUMAN ALPHA DEFENSIN 1, HUMAN NEUTROPHIL PEPTIDE 1, ANTIBIOTIC, ANTIVIRAL DEFENSE, DEFENSIN, DISULFIDE BOND, FUNGICIDE, PHOSPHOPROTEIN, SECRETED, ANTIMICROBIAL PROTEIN
Molecular Weight	27.04 kDa
Entity Count	Protein: 1, Nucleic Acid: 0, NA Hybrid: 0
Space Group	C 1 2 1
Cell Parameters	a=75.00 Å, b=62.58 Å, c=42.50 Å, α=90.00°, β=99.69°, γ=90.00°
Disulfide Bond	A2-A30;A4-A19;A9-A29;B2-B30;B4-B19;B9-B29;C2-C30;C4-C19;C9-C29;D2-D30;D4-D19;D9-D29;E2-E30;E4-E19;E9-E29;F2-F30;F4-F19;F9-F29;G2-G30;G4-G19;G9-G29;H2-H30;H4-H19;H9-H29
Peptide Chains	A, B, C, D, E, F, G, H
Peptide Lengths	30

Sequence Information

Chain: A, B, C, D, E, F, G, H - Neutrophil defensin 1 (Length: 30)

1	ACYCRIPACI AGERRYGTCA YQGRAWAFCC

References

Single, Double and Quadruple Alanine Substitutions at Oligomeric Interfaces Identify Hydrophobicity as the Key Determinant of Human Neutrophil Alpha Defensin HNP1 Function.

Zhao, L., Tolbert, W.D., Ericksen, B., Zhan, C., Wu, X., Yuan, W., Li, X., Pazgier, M., Lu, W.

PLoS One, 2013

PubMed: 24236072 | DOI: 10.1371/journal.pone.0078937

Ligand Information

ID	Name	Formula	Molecular Weight
GOL	GLYCEROL	C3 H8 O3	92.094

Biological Assemblies

Assembly ID: 1

Details: author_and_software_defined_assembly

Oligomeric State: Homo 4-mer

Stoichiometry: A4

Assembly ID: 2