4WWW - Cyclic Peptide Structure

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Summary

PDB ID	4WWW Go to RCSB ➚
Title	Crystal structure of the E. coli ribosome bound to CEM-101
Method	X-RAY DIFFRACTION
Resolution	3.10 Å
R-factors	R-work: 0.200, R-free: 0.252
Release Date	2014-12-24
Authors	Dunkle, J.A.; Zhang, W.; Cate, J.H.D.; Mankin, A.S.
Source Organism	Escherichia coli, Escherichia coli str. K-12 substr. MG1655
Keywords	ribosomes, 70S, macrolide, ketolide, Ribosome-antibiotic complex
Molecular Weight	4237.89 kDa
Entity Count	Protein: 49, Nucleic Acid: 3, NA Hybrid: 0
Space Group	P 21 21 21
Cell Parameters	a=210.76 Å, b=433.27 Å, c=618.86 Å, α=90.00°, β=90.00°, γ=90.00°
Disulfide Bond	R411-R427
Other Links	Yes
Peptide Chains	R2, R4, Y2, Y4
Protein Chains	QA, QB, QC, QD, QE, QF, QG, QH, QI, QJ, QK, QL, QM, QN, QO, QP, QQ, QR, QS, QT, QU, R0, R1, R3, RA, RB, RC, RD, RE, RF, RG, RH, RI, RJ, RK, RL, RM, RN, RO, RP, RQ, RR, RS, RT, RU, RV, RW, RX, RY, RZ, XA, XB, XC, XD, XE, XF, XG, XH, XI, XJ, XK, XL, XM, XN, XO, XP, XQ, XR, XS, XT, XU, Y0, Y1, Y3, YA, YB, YC, YD, YE, YF, YG, YH, YI, YJ, YK, YL, YM, YN, YO, YP, YQ, YR, YS, YT, YU, YV, YW, YX, YY, YZ
Peptide Lengths	46, 38
Protein Lengths	2904, 271, 209, 201, 178, 176, 149, 141, 142, 122, 143, 136, 120, 116, 114, 117, 103, 110, 93, 102, 94, 79, 77, 63, 58, 56, 50, 64, 1533, 218, 206, 205, 150, 100, 151, 129, 127, 98, 117, 123, 114, 101, 88, 82, 80, 55, 79, 85, 51, 118

Sequence Information

Chain: RA, YA - 23S rRNA (Length: 2904)

1	GGUUAAGCGA CUAAGCGUAC ACGGUGGAUG CCCUGGCAGU CAGAGGCGAU GAAGGACGUG
61	CUAAUCUGCG AUAAGCGUCG GUAAGGUGAU AUGAACCGUU AUAACCGGCG AUUUCCGAAU
121	GGGGAAACCC AGUGUGUUUC GACACACUAU CAUUAACUGA AUCCAUAGGU UAAUGAGGCG
181	AACCGGGGGA ACUGAAACAU CUAAGUACCC CGAGGAAAAG AAAUCAACCG AGAUUCCCCC
241	AGUAGCGGCG AGCGAACGGG GAGCAGCCCA GAGCCUGAAU CAGUGUGUGU GUUAGUGGAA
301	GCGUCUGGAA AGGCGCGCGA UACAGGGUGA CAGCCCCGUA CACAAAAAUG CACAUGCUGU
361	GAGCUCGAUG AGUAGGGCGG GACACGUGGU AUCCUGUCUG AAUAUGGGGG GACCAUCCUC
421	CAAGGCUAAA UACUCCUGAC UGACCGAUAG UGAACCAGUA CCGUGAGGGA AAGGCGAAAA
481	GAACCCCGGC GAGGGGAGUG AAAAAGAACC UGAAACCGUG UACGUACAAG CAGUGGGAGC
541	ACGCUUAGGC GUGUGACUGC GUACCUUUUG UAUAAUGGGU CAGCGACUUA UAUUCUGUAG
601	CAAGGUUAAC CGAAUAGGGG AGCCGAAGGG AAACCGAGUC UUAACUGGGC GUUAAGUUGC
661	AGGGUAUAGA CCCGAAACCC GGUGAUCUAG CCAUGGGCAG GUUGAAGGUU GGGUAACACU
721	AACUGGAGGA CCGAACCGAC UAAUGUUGAA AAAUUAGCGG AUGACUUGUG GCUGGGGGUG
781	AAAGGCCAAU CAAACCGGGA GAUAGCUGGU UCUCCCCGAA AGCUAUUUAG GUAGCGCCUC
841	GUGAAUUCAU CUCCGGGGGU AGAGCACUGU UUCGGCAAGG GGGUCAUCCC GACUUACCAA
901	CCCGAUGCAA ACUGCGAAUA CCGGAGAAUG UUAUCACGGG AGACACACGG CGGGUGCUAA
961	CGUCCGUCGU GAAGAGGGAA ACAACCCAGA CCGCCAGCUA AGGUCCCAAA GUCAUGGUUA
1021	AGUGGGAAAC GAUGUGGGAA GGCCCAGACA GCCAGGAUGU UGGCUUAGAA GCAGCCAUCA
1081	UUUAAAGAAA GCGUAAUAGC UCACUGGUCG AGUCGGCCUG CGCGGAAGAU GUAACGGGGC
1141	UAAACCAUGC ACCGAAGCUG CGGCAGCGAC GCUUAUGCGU UGUUGGGUAG GGGAGCGUUC
1201	UGUAAGCCUG CGAAGGUGUG CUGUGAGGCA UGCUGGAGGU AUCAGAAGUG CGAAUGCUGA
1261	CAUAAGUAAC GAUAAAGCGG GUGAAAAGCC CGCUCGCCGG AAGACCAAGG GUUCCUGUCC
1321	AACGUUAAUC GGGGCAGGGU GAGUCGACCC CUAAGGCGAG GCCGAAAGGC GUAGUCGAUG
1381	GGAAACAGGU UAAUAUUCCU GUACUUGGUG UUACUGCGAA GGGGGGACGG AGAAGGCUAU
1441	GUUGGCCGGG CGACGGUUGU CCCGGUUUAA GCGUGUAGGC UGGUUUUCCA GGCAAAUCCG
1501	GAAAAUCAAG GCUGAGGCGU GAUGACGAGG CACUACGGUG CUGAAGCAAC AAAUGCCCUG
1561	CUUCCAGGAA AAGCCUCUAA GCAUCAGGUA ACAUCAAAUC GUACCCCAAA CCGACACAGG
1621	UGGUCAGGUA GAGAAUACCA AGGCGCUUGA GAGAACUCGG GUGAAGGAAC UAGGCAAAAU
1681	GGUGCCGUAA CUUCGGGAGA AGGCACGCUG AUAUGUAGGU GAGGUCCCUC GCGGAUGGAG
1741	CUGAAAUCAG UCGAAGAUAC CAGCUGGCUG CAACUGUUUA UUAAAAACAC AGCACUGUGC
1801	AAACACGAAA GUGGACGUAU ACGGUGUGAC GCCUGCCCGG UGCCGGAAGG UUAAUUGAUG
1861	GGGUUAGCGC AAGCGAAGCU CUUGAUCGAA GCCCCGGUAA ACGGCGGCCG UAACUAUAAC
1921	GGUCCUAAGG UAGCGAAAUU CCUUGUCGGG UAAGUUCCGA CCUGCACGAA UGGCGUAAUG
1981	AUGGCCAGGC UGUCUCCACC CGAGACUCAG UGAAAUUGAA CUCGCUGUGA AGAUGCAGUG
2041	UACCCGCGGC AAGACGGAAA GACCCCGUGA ACCUUUACUA UAGCUUGACA CUGAACAUUG
2101	AGCCUUGAUG UGUAGGAUAG GUGGGAGGCU UUGAAGUGUG GACGCCAGUC UGCAUGGAGC
2161	CGACCUUGAA AUACCACCCU UUAAUGUUUG AUGUUCUAAC GUUGACCCGU AAUCCGGGUU
2221	GCGGACAGUG UCUGGUGGGU AGUUUGACUG GGGCGGUCUC CUCCUAAAGA GUAACGGAGG
2281	AGCACGAAGG UUGGCUAAUC CUGGUCGGAC AUCAGGAGGU UAGUGCAAUG GCAUAAGCCA
2341	GCUUGACUGC GAGCGUGACG GCGCGAGCAG GUGCGAAAGC AGGUCAUAGU GAUCCGGUGG
2401	UUCUGAAUGG AAGGGCCAUC GCUCAACGGA UAAAAGGUAC UCCGGGGAUA ACAGGCUGAU
2461	ACCGCCCAAG AGUUCAUAUC GACGGCGGUG UUUGGCACCU CGAUGUCGGC UCAUCACAUC
2521	CUGGGGCUGA AGUAGGUCCC AAGGGUAUGG CUGUUCGCCA UUUAAAGUGG UACGCGAGCU
2581	GGGUUUAGAA CGUCGUGAGA CAGUUCGGUC CCUAUCUGCC GUGGGCGCUG GAGAACUGAG
2641	GGGGGCUGCU CCUAGUACGA GAGGACCGGA GUGGACGCAU CACUGGUGUU CGGGUUGUCA
2701	UGCCAAUGGC ACUGCCCGGU AGCUAAAUGC GGAAGAGAUA AGUGCUGAAA GCAUCUAAGC
2761	ACGAAACUUG CCCCGAGAUG AGUUCUCCCU GACCCUUUAA GGGUCCUGAA GGAACGUUGA
2821	AGACGACGAC GUUGAUAGGC CGGGUGUGUA AGCGCAGCGA UGCGUUGAGC UAACCGGUAC
2881	UAAUGAACCG UGAGGCUUAA CCUU

Chain: RC, YC - 50S ribosomal protein L2 (Length: 271)

1	AVVKCKPTSP GRRHVVKVVN PELHKGKPFA PLLEKNSKSG GRNNNGRITT RHIGGGHKQA
61	YRIVDFKRNK DGIPAVVERL EYDPNRSANI ALVLYKDGER RYILAPKGLK AGDQIQSGVD
121	AAIKPGNTLP MRNIPVGSTV HNVEMKPGKG GQLARSAGTY VQIVARDGAY VTLRLRSGEM
181	RKVEADCRAT LGEVGNAEHM LRVLGKAGAA RWRGVRPTVR GTAMNPVDHP HGGGEGRNFG
241	KHPVTPWGVQ TKGKKTRSNK RTDKFIVRRR S

Chain: RD, YD - 50S ribosomal protein L3 (Length: 209)

1	MIGLVGKKVG MTRIFTEDGV SIPVTVIEVE ANRVTQVKDL ANDGYRAIQV TTGAKKANRV
61	TKPEAGHFAK AGVEAGRGLW EFRLAEGEEF TVGQSISVEL FADVKKVDVT GTSKGKGFAG
121	TVKRWNFRTQ DATHGNSLSH RVPGSIGQNQ TPGKVFKGKK MAGQMGNERV TVQSLDVVRV
181	DAERNLLLVK GAVPGATGSD LIVKPAVKA

Chain: RE, YE - 50S ribosomal protein L4 (Length: 201)

1	MELVLKDAQS ALTVSETTFG RDFNEALVHQ VVVAYAAGAR QGTRAQKTRA EVTGSGKKPW
61	RQKGTGRARS GSIKSPIWRS GGVTFAARPQ DHSQKVNKKM YRGALKSILS ELVRQDRLIV
121	VEKFSVEAPK TKLLAQKLKD MALEDVLIIT GELDENLFLA ARNLHKVDVR DATGIDPVSL
181	IAFDKVVMTA DAVKQVEEML A

Chain: RF, YF - 50S ribosomal protein L5 (Length: 178)

1	AKLHDYYKDE VVKKLMTEFN YNSVMQVPRV EKITLNMGVG EAIADKKLLD NAAADLAAIS
61	GQKPLITKAR KSVAGFKIRQ GYPIGCKVTL RGERMWEFFE RLITIAVPRI RDFRGLSAKS
121	FDGRGNYSMG VREQIIFPEI DYDKVDRVRG LDITITTTAK SDEEGRALLA AFDFPFRK

Chain: RG, YG - 50S ribosomal protein L6 (Length: 176)

1	SRVAKAPVVV PAGVDVKING QVITIKGKNG ELTRTLNDAV EVKHADNTLT FGPRDGYADG
61	WAQAGTARAL LNSMVIGVTE GFTKKLQLVG VGYRAAVKGN VINLSLGFSH PVDHQLPAGI
121	TAECPTQTEI VLKGADKQVI GQVAADLRAY RRPEPYKGKG VRYADEVVRT KEAKKK

Chain: RH, YH - 50S ribosomal protein L9 (Length: 149)

1	MQVILLDKVA NLGSLGDQVN VKAGYARNFL VPQGKAVPAT KKNIEFFEAR RAELEAKLAE
61	VLAAANARAE KINALETVTI ASKAGDEGKL FGSIGTRDIA DAVTAAGVEV AKSEVRLPNG
121	VLRTTGEHEV SFQVHSEVFA KVIVNVVAE

Chain: RI, YI - 50S ribosomal protein L11 (Length: 141)

1	AKKVQAYVKL QVAAGMANPS PPVGPALGQQ GVNIMEFCKA FNAKTDSIEK GLPIPVVITV
61	YADRSFTFVT KTPPAAVLLK KAAGIKSGSG KPNKDKVGKI SRAQLQEIAQ TKAADMTGAD
121	IEAMTRSIEG TARSMGLVVE D

Chain: RJ, YJ - 50S ribosomal protein L13 (Length: 142)

1	MKTFTAKPET VKRDWYVVDA TGKTLGRLAT ELARRLRGKH KAEYTPHVDT GDYIIVLNAD
61	KVAVTGNKRT DKVYYHHTGH IGGIKQATFE EMIARRPERV IEIAVKGMLP KGPLGRAMFR
121	KLKVYAGNEH NHAAQQPQVL DI

Chain: RK, YK - 50S ribosomal protein L14 (Length: 122)

1	MIQEQTMLNV ADNSGARRVM CIKVLGGSHR RYAGVGDIIK ITIKEAIPRG KVKKGDVLKA
61	VVVRTKKGVR RPDGSVIRFD GNACVLLNNN SEQPIGTRIF GPVTRELRSE KFMKIISLAP
121	EV

Chain: RL, YL - 50S ribosomal protein L15 (Length: 143)

1	RLNTLSPAEG SKKAGKRLGR GIGSGLGKTG GRGHKGQKSR SGGGVRRGFE GGQMPLYRRL
61	PKFGFTSRKA AITAEIRLSD LAKVEGGVVD LNTLKAANII GIQIEFAKVI LAGEVTTPVT
121	VRGLRVTKGA RAAIEAAGGK IEE

Chain: RM, YM - 50S ribosomal protein L16 (Length: 136)

1	MLQPKRTKFR KMHKGRNRGL AQGTDVSFGS FGLKAVGRGR LTARQIEAAR RAMTRAVKRQ
61	GKIWIRVFPD KPITEKPLAV RMGKGKGNVE YWVALIQPGK VLYEMDGVPE ELAREAFKLA
121	AAKLPIKTTF VTKTVM

Chain: RN, YN - 50S ribosomal protein L17 (Length: 120)

1	MRHRKSGRQL NRNSSHRQAM FRNMAGSLVR HEIIKTTLPK AKELRRVVEP LITLAKTDSV
61	ANRRLAFART RDNEIVAKLF NELGPRFASR AGGYTRILKC GFRAGDNAPM AYIELVDRSE

Chain: RO, YO - 50S ribosomal protein L18 (Length: 116)

1	DKKSARIRRA TRARRKLQEL GATRLVVHRT PRHIYAQVIA PNGSEVLVAA STVEKAIAEQ
61	LKYTGNKDAA AAVGKAVAER ALEKGIKDVS FDRSGFQYHG RVQALADAAR EAGLQF

Chain: RP, YP - 50S ribosomal protein L19 (Length: 114)

1	SNIIKQLEQE QMKQDVPSFR PGDTVEVKVW VVEGSKKRLQ AFEGVVIAIR NRGLHSAFTV
61	RKISNGEGVE RVFQTHSPVV DSISVKRRGA VRKAKLYYLR ERTGKAARIK ERLN

Chain: RQ, YQ - 50S ribosomal protein L20 (Length: 117)

1	ARVKRGVIAR ARHKKILKQA KGYYGARSRV YRVAFQAVIK AGQYAYRDRR QRKRQFRQLW
61	IARINAAARQ NGISYSKFIN GLKKASVEID RKILADIAVF DKVAFTALVE KAKAALA

Chain: RR, YR - 50S ribosomal protein L21 (Length: 103)

1	MYAVFQSGGK QHRVSEGQTV RLEKLDIATG ETVEFAEVLM IANGEEVKIG VPFVDGGVIK
61	AEVVAHGRGE KVKIVKFRRR KHYRKQQGHR QWFTDVKITG ISA

Chain: RS, YS - 50S ribosomal protein L22 (Length: 110)

1	METIAKHRHA RSSAQKVRLV ADLIRGKKVS QALDILTYTN KKAAVLVKKV LESAIANAEH
61	NDGADIDDLK VTKIFVDEGP SMKRIMPRAK GRADRILKRT SHITVVVSDR

Chain: RT, YT - 50S ribosomal protein L23 (Length: 93)

1	MIREERLLKV LRAPHVSEKA STAMEKSNTI VLKVAKDATK AEIKAAVQKL FEVEVEVVNT
61	LVVKGKVKRH GQRIGRRSDW KKAYVTLKEG QNL

Chain: RU, YU - 50S ribosomal protein L24 (Length: 102)

1	AAKIRRDDEV IVLTGKDKGK RGKVKNVLSS GKVIVEGINL VKKHQKPVPA LNQPGGIVEK
61	EAAIQVSNVA IFNAATGKAD RVGFRFEDGK KVRFFKSNSE TI

Chain: RV, YV - 50S ribosomal protein L25 (Length: 94)

1	MFTINAEVRK EQGKGASRRL RAANKFPAII YGGKEAPLAI ELDHDKVMNM QAKAEFYSEV
61	LTIVVDGKEI KVKAQDVQRH PYKPKLQHID FVRA

Chain: RW, YW - 50S ribosomal protein L27 (Length: 79)

1	GGSTRNGRDS EAKRLGVKRF GGESVLAGSI IVRQRGTKFH AGANVGCGRD HTLFAKADGK
61	VKFEVKGPKN RKFISIEAE

Chain: RX, YX - 50S ribosomal protein L28 (Length: 77)

1	SRVCQVTGKR PVTGNNRSHA LNATKRRFLP NLHSHRFWVE SEKRFVTLRV SAKGMRVIDK
61	KGIDTVLAEL RARGEKY

Chain: RY, YY - 50S ribosomal protein L29 (Length: 63)

1	MKAKELREKS VEELNTELLN LLREQFNLRM QAASGQLQQS HLLKQVRRDV ARVKTLLNEK
61	AGA

Chain: RZ, YZ - 50S ribosomal protein L30 (Length: 58)

1	AKTIKITQTR SAIGRLPKHK ATLLGLGLRR IGHTVEREDT PAIRGMINAV SFMVKVEE

Chain: R0, Y0 - 50S ribosomal protein L32 (Length: 56)

1	AVQQNKPTRS KRGMRRSHDA LTAVTSLSVD KTSGEKHLRH HITADGYYRG RKVIAK

Chain: R1, Y1 - 50S ribosomal protein L33 (Length: 50)

1	GIREKIKLVS SAGTGHFYTT TKNKRTKPEK LELKKFDPVV RQHVIYKEAK

Chain: R2, Y2 - 50S ribosomal protein L34 (Length: 46)

1	MKRTFQPSVL KRNRSHGFRA RMATKNGRQV LARRRAKGRA RLTVSK

Chain: R3, Y3 - 50S ribosomal protein L35 (Length: 64)

1	PKIKTVRGAA KRFKKTGKGG FKHKHANLRH ILTKKATKRK RHLRPKAMVS KGDLGLVIAC
61	LPYA

Chain: R4, Y4 - 50S ribosomal protein L36 (Length: 38)

1	MKVRASVKKL CRNCKIVKRD GVIRVICSAE PKHKQRQG

Chain: QA, XA - 16S rRNA (Length: 1533)

1	AAUUGAAGAG UUUGAUCAUG GCUCAGAUUG AACGCUGGCG GCAGGCCUAA CACAUGCAAG
61	UCGAACGGUA ACAGGAAGAA GCUUGCUUCU UUGCUGACGA GUGGCGGACG GGUGAGUAAU
121	GUCUGGGAAA CUGCCUGAUG GAGGGGGAUA ACUACUGGAA ACGGUAGCUA AUACCGCAUA
181	ACGUCGCAAG ACCAAAGAGG GGGACCUUCG GGCCUCUUGC CAUCGGAUGU GCCCAGAUGG
241	GAUUAGCUAG UAGGUGGGGU AACGGCUCAC CUAGGCGACG AUCCCUAGCU GGUCUGAGAG
301	GAUGACCAGC CACACUGGAA CUGAGACACG GUCCAGACUC CUACGGGAGG CAGCAGUGGG
361	GAAUAUUGCA CAAUGGGCGC AAGCCUGAUG CAGCCAUGCC GCGUGUAUGA AGAAGGCCUU
421	CGGGUUGUAA AGUACUUUCA GCGGGGAGGA AGGGAGUAAA GUUAAUACCU UUGCUCAUUG
481	ACGUUACCCG CAGAAGAAGC ACCGGCUAAC UCCGUGCCAG CAGCCGCGGU AAUACGGAGG
541	GUGCAAGCGU UAAUCGGAAU UACUGGGCGU AAAGCGCACG CAGGCGGUUU GUUAAGUCAG
601	AUGUGAAAUC CCCGGGCUCA ACCUGGGAAC UGCAUCUGAU ACUGGCAAGC UUGAGUCUCG
661	UAGAGGGGGG UAGAAUUCCA GGUGUAGCGG UGAAAUGCGU AGAGAUCUGG AGGAAUACCG
721	GUGGCGAAGG CGGCCCCCUG GACGAAGACU GACGCUCAGG UGCGAAAGCG UGGGGAGCAA
781	ACAGGAUUAG AUACCCUGGU AGUCCACGCC GUAAACGAUG UCGACUUGGA GGUUGUGCCC
841	UUGAGGCGUG GCUUCCGGAG CUAACGCGUU AAGUCGACCG CCUGGGGAGU ACGGCCGCAA
901	GGUUAAAACU CAAAUGAAUU GACGGGGGCC CGCACAAGCG GUGGAGCAUG UGGUUUAAUU
961	CGAUGCAACG CGAAGAACCU UACCUGGUCU UGACAUCCAC GGAAGUUUUC AGAGAUGAGA
1021	AUGUGCCUUC GGGAACCGUG AGACAGGUGC UGCAUGGCUG UCGUCAGCUC GUGUUGUGAA
1081	AUGUUGGGUU AAGUCCCGCA ACGAGCGCAA CCCUUAUCCU UUGUUGCCAG CGGUCCGGCC
1141	GGGAACUCAA AGGAGACUGC CAGUGAUAAA CUGGAGGAAG GUGGGGAUGA CGUCAAGUCA
1201	UCAUGGCCCU UACGACCAGG GCUACACACG UGCUACAAUG GCGCAUACAA AGAGAAGCGA
1261	CCUCGCGAGA GCAAGCGGAC CUCAUAAAGU GCGUCGUAGU CCGGAUUGGA GUCUGCAACU
1321	CGACUCCAUG AAGUCGGAAU CGCUAGUAAU CGUGGAUCAG AAUGCCACGG UGAAUACGUU
1381	CCCGGGCCUU GUACACACCG CCCGUCACAC CAUGGGAGUG GGUUGCAAAA GAAGUAGGUA
1441	GCUUAACCUU CGGGAGGGCG CUUACCACUU UGUGAUUCAU GACUGGGGUG AAGUCGUAAC
1501	AAGGUAACCG UAGGGGAACC UGCGGUUGGA UCA

Chain: QB, XB - 30S ribosomal protein S2 (Length: 218)

1	MLKAGVHFGH QTRYWNPKMK PFIFGARNKV HIINLEKTVP MFNEALAELN KIASRKGKIL
61	FVGTKRAASE AVKDAALSCD QFFVNHRWLG GMLTNWKTVR QSIKRLKDLE TQSQDGTFDK
121	LTKKEALMRT RELEKLENSL GGIKDMGGLP DALFVIDADH EHIAIKEANN LGIPVFAIVD
181	TNSDPDGVDF VIPGNDDAIR AVTLYLGAVA ATVREGRS

Chain: QC, XC - 30S ribosomal protein S3 (Length: 206)

1	GQKVHPNGIR LGIVKPWNST WFANTKEFAD NLDSDFKVRQ YLTKELAKAS VSRIVIERPA
61	KSIRVTIHTA RPGIVIGKKG EDVEKLRKVV ADIAGVPAQI NIAEVRKPEL DAKLVADSIT
121	SQLERRVMFR RAMKRAVQNA MRLGAKGIKV EVSGRLGGAE IARTEWYREG RVPLHTLRAD
181	IDYNTSEAHT TYGVIGVKVW IFKGEI

Chain: QD, XD - 30S ribosomal protein S4 (Length: 205)

1	ARYLGPKLKL SRREGTDLFL KSGVRAIDTK CKIEQAPGQH GARKPRLSDY GVQLREKQKV
61	RRIYGVLERQ FRNYYKEAAR LKGNTGENLL ALLEGRLDNV VYRMGFGATR AEARQLVSHK
121	AIMVNGRVVN IASYQVSPND VVSIREKAKK QSRVKAALEL AEQREKPTWL EVDAGKMEGT
181	FKRKPERSDL SADINEHLIV ELYSK

Chain: QE, XE - 30S ribosomal protein S5 (Length: 150)

1	ELQEKLIAVN RVSKTVKGGR IFSFTALTVV GDGNGRVGFG YGKAREVPAA IQKAMEKARR
61	NMINVALNNG TLQHPVKGVH TGSRVFMQPA SEGTGIIAGG AMRAVLEVAG VHNVLAKAYG
121	STNPINVVRA TIDGLENMNS PEMVAAKRGK

Chain: QF, XF - 30S ribosomal protein S6 (Length: 100)

1	MRHYEIVFMV HPDQSEQVPG MIERYTAAIT GAEGKIHRLE DWGRRQLAYP INKLHKAHYV
61	LMNVEAPQEV IDELETTFRF NDAVIRSMVM RTKHAVTEAS

Chain: QG, XG - 30S ribosomal protein S7 (Length: 151)

1	PRRRVIGQRK ILPDPKFGSE LLAKFVNILM VDGKKSTAES IVYSALETLA QRSGKSELEA
61	FEVALENVRP TVEVKSRRVG GSTYQVPVEV RPVRRNALAM RWIVEAARKR GDKSMALRLA
121	NELSDAAENK GTAVKKREDV HRMAEANKAF A

Chain: QH, XH - 30S ribosomal protein S8 (Length: 129)

1	SMQDPIADML TRIRNGQAAN KAAVTMPSSK LKVAIANVLK EEGFIEDFKV EGDTKPELEL
61	TLKYFQGKAV VESIQRVSRP GLRIYKRKDE LPKVMAGLGI AVVSTSKGVM TDRAARQAGL
121	GGEIICYVA

Chain: QI, XI - 30S ribosomal protein S9 (Length: 127)

1	NQYYGTGRRK SSAARVFIKP GNGKIVINQR SLEQYFGRET ARMVVRQPLE LVDMVEKLDL
61	YITVKGGGIS GQAGAIRHGI TRALMEYDES LRSELRKAGF VTRDARQVER KKVGLRKARR
121	RPQFSKR

Chain: QJ, XJ - 30S ribosomal protein S10 (Length: 98)

1	RIRIRLKAFD HRLIDQATAE IVETAKRTGA QVRGPIPLPT RKERFTVLIS PHVNKDARDQ
61	YEIRTHLRLV DIVEPTEKTV DALMRLDLAA GVDVQISL

Chain: QK, XK - 30S ribosomal protein S11 (Length: 117)

1	RKQVSDGVAH IHASFNNTIV TITDRQGNAL GWATAGGSGF RGSRKSTPFA AQVAAERCAD
61	AVKEYGIKNL EVMVKGPGPG RESTIRALNA AGFRITNITD VTPIPHNGCR PPKKRRV

Chain: QL, XL - 30S ribosomal protein S12 (Length: 123)

1	ATVNQLVRKP RARKVAKSNV PALEACPQKR GVCTRVYTTT PKKPNSALRK VCRVRLTNGF
61	EVTSYIGGEG HNLQEHSVIL IRGGRVKDLP GVRYHTVRGA LDCSGVKDRK QARSKYGVKR
121	PKA

Chain: QM, XM - 30S ribosomal protein S13 (Length: 114)

1	ARIAGINIPD HKHAVIALTS IYGVGKTRSK AILAAAGIAE DVKISELSEG QIDTLRDEVA
61	KFVVEGDLRR EISMSIKRLM DLGCYRGLRH RRGLPVRGQR TKTNARTRKG PRKP

Chain: QN, XN - 30S ribosomal protein S14 (Length: 101)

1	MAKQSMKARE VKRVALADKY FAKRAELKAI ISDVNASDED RWNAVLKLQT LPRDSSPSRQ
61	RNRCRQTGRP HGFLRKFGLS RIKVREAAMR GEIPGLKKAS W

Chain: QO, XO - 30S ribosomal protein S15 (Length: 88)

1	SLSTEATAKI VSEFGRDAND TGSTEVQVAL LTAQINHLQG HFAEHKKDHH SRRGLLRMVS
61	QRRKLLDYLK RKDVARYTQL IERLGLRR

Chain: QP, XP - 30S ribosomal protein S16 (Length: 82)

1	MVTIRLARHG AKKRPFYQVV VADSRNARNG RFIERVGFFN PIASEKEEGT RLDLDRIAHW
61	VGQGATISDR VAALIKEVNK AA

Chain: QQ, XQ - 30S ribosomal protein S17 (Length: 80)

1	KIRTLQGRVV SDKMEKSIVV AIERFVKHPI YGKFIKRTTK LHVHDENNEC GIGDVVEIRE
61	CRPLSKTKSW TLVRVVEKAV

Chain: QR, XR - 30S ribosomal protein S18 (Length: 55)

1	EIDYKDIATL KNYITESGKI VPSRITGTRA KYQRQLARAI KRARYLSLLP YTDRH

Chain: QS, XS - 30S ribosomal protein S19 (Length: 79)

1	RSLKKGPFID LHLLKKVEKA VESGDKKPLR TWSRRSTIFP NMIGLTIAVH NGRQHVPVFV
61	TDEMVGHKLG EFAPTRTYR

Chain: QT, XT - 30S ribosomal protein S20 (Length: 85)

1	NIKSAKKRAI QSEKARKHNA SRRSMMRTFI KKVYAAIEAG DKAAAQKAFN EMQPIVDRQA
61	AKGLIHKNKA ARHKANLTAQ INKLA

Chain: QU, XU - 30S ribosomal protein S21 (Length: 51)

1	IKVRENEPFD VALRRFKRSC EKAGVLAEVR RREFYEKPTT ERKRAKASAV K

Chain: RB, YB - 5S rRNA (Length: 118)

1	GCCUGGCGGC CGUAGCGCGG UGGUCCCACC UGACCCCAUG CCGAACUCAG AAGUGAAACG
61	CCGUAGCGCC GAUGGUAGUG UGGGGUCUCC CCAUGCGAGA GUAGGGAACU GCCAGGCA

References

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.

Llano-Sotelo, B., Dunkle, J., Klepacki, D., Zhang, W., Fernandes, P., Cate, J.H., Mankin, A.S.

Antimicrob Agents Chemother, 2010

PubMed: 20855725 | DOI: 10.1128/AAC.00860-10

Ligand Information

ID	Name	Formula	Molecular Weight
MG	MAGNESIUM ION	Mg	24.305
EM1	(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside	C43 H65 F N6 O10	845.009
ZN	ZINC ION	Zn	65.409

Biological Assemblies

Assembly ID: 1

Details: author_defined_assembly

Oligomeric State: Hetero 49-mer

Stoichiometry: A1, B1, C1, D1, E1, F1, G1, H1, I1, J1, K1, L1, M1, N1, O1, P1, Q1, R1, S1, T1, U1, V1, W1, X1, Y1, Z1, a1, b1, c1, d1, e1, f1, g1, h1, i1, j1, k1, l1, m1, n1, o1, p1, q1, r1, s1, t1, u1, v1, w1

Assembly ID: 2