Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	5EMS Go to RCSB ➚
Title	Crystal Structure of an iodinated insulin analog
Method	X-RAY DIFFRACTION
Resolution	2.30 Å
R-factors	R-work: 0.163, R-free: 0.233
Release Date	2016-11-16
Authors	Lawrence, M.C.; Pandyarajan, V.; Wan, Z.; Weiss, M.A.
Source Organism	Homo sapiens
Keywords	insulin, hormone, non-standard modification, protein design, protein engineering
Molecular Weight	36.33 kDa
Entity Count	Protein: 2, Nucleic Acid: 0, NA Hybrid: 0
Space Group	P 1 21 1
Cell Parameters	a=46.43 Å, b=61.63 Å, c=58.58 Å, α=90.00°, β=111.38°, γ=90.00°
Disulfide Bond	A6-A11;C6-C11;E6-E11;G6-G11;I6-I11;K6-K11
Other Links	Yes
Peptide Chains	A, B, C, D, E, F, G, H, I, J, K, L
Peptide Lengths	21, 30

1	GIVEQCCTSI CSLYQLENYC N

1	FVNQHLCGSH LVEALYLVCG ERGFFYTPLT

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.

El Hage, K., Pandyarajan, V., Phillips, N.B., Smith, B.J., Menting, J.G., Whittaker, J., Lawrence, M.C., Meuwly, M., Weiss, M.A.

J Biological Chem, 2016

ID	Name	Formula	Molecular Weight
IPH	PHENOL	C6 H6 O	94.111
ZN	ZINC ION	Zn	65.409
CL	CHLORIDE ION	Cl	35.453

Assembly ID: 1

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 12-mer

Stoichiometry: A6, B6