Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	5GRG Go to RCSB ➚
Title	Crystal structure of dual peptide from EBV in complex with HLA-A*11:01
Method	X-RAY DIFFRACTION
Resolution	1.94 Å
R-factors	R-work: 0.189, R-free: 0.243
Release Date	2017-08-09
Authors	Tadwal, V.S.; Xiao, Z.; Ren, E.C.
Source Organism	Homo sapiens, synthetic construct
Expression Host	Escherichia coli BL21(DE3)
Gene Names	B2M, CDABP0092, HDCMA22P, HLA-A, HLAA
Keywords	Immune System, Human Leukocyte Antigen
Molecular Weight	44.99 kDa
Entity Count	Protein: 4, Nucleic Acid: 0, NA Hybrid: 0
Space Group	P 21 21 21
Cell Parameters	a=55.25 Å, b=67.43 Å, c=115.02 Å, α=90.00°, β=90.00°, γ=90.00°
Disulfide Bond	C3-C6
Peptide Chains	C, D
Protein Chains	A, B
Peptide Lengths	6, 4
Protein Lengths	275, 99

1	GSHSMRYFYT SVSRPGRGEP RFIAVGYVDD TQFVRFDSDA ASQRMEPRAP WIEQEGPEYW
61	DQETRNVKAQ SQTDRVDLGT LRGYYNQSED GSHTIQIMYG CDVGPDGRFL RGYRQDAYDG
121	KDYIALNEDL RSWTAADMAA QITKRKWEAA HAAEQQRAYL EGRCVEWLRR YLENGKETLQ
181	RTDPPKTHMT HHPISDHEAT LRCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPAGDGT
241	FQKWAAVVVP SGEEQRYTCH VQHEGLPKPL TLRWE

1	IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW
61	SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM

1

SSCSSC

1

PLSK

Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens

Xiao, Z., Ye, Z., Tadwal, V.S., Shen, M., Ren, E.C.

Sci Rep, 2017

ID	Name	Formula	Molecular Weight
GOL	GLYCEROL	C3 H8 O3	92.094

Assembly ID: 1

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 4-mer

Stoichiometry: A1, B1, C1, D1