Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	6AVC Go to RCSB ➚
Title	Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
Method	X-RAY DIFFRACTION
Resolution	1.88 Å
R-factors	R-work: 0.161, R-free: 0.238
Release Date	2018-02-28
Authors	Gewe, M.M.; Rupert, P.; Strong, R.K.
Source Organism	Mesobuthus martensii
Expression Host	Homo sapiens
Keywords	Knottins, Cystine knot, Toxins, TOXIN
Molecular Weight	4.34 kDa
Entity Count	Protein: 1, Nucleic Acid: 0, NA Hybrid: 0
Space Group	P 32 2 1
Cell Parameters	a=43.45 Å, b=43.45 Å, c=32.08 Å, α=90.00°, β=90.00°, γ=120.00°
Disulfide Bond	A9-A30;A15-A35;A19-A37
Peptide Chains	A
Peptide Lengths	39

Sequence Information

Chain: A - Potassium channel toxin alpha-KTx 1.5 (Length: 39)

1	GSQFTDVKCT GSKQCWPVCK QMFGKPNGKC MNGKCRCYS

References

Screening, large-scale production and structure-based classification of cystine-dense peptides.

Correnti, C.E., Gewe, M.M., Mehlin, C., Bandaranayake, A.D., Johnsen, W.A., Rupert, P.B., Brusniak, M.Y., Clarke, M., Burke, S.E., De Van Der Schueren, W., Pilat, K., Turnbaugh, S.M., May, D., Watson, A., Chan, M.K., Bahl, C.D., Olson, J.M., Strong, R.K.

Nat Struct Mol Biol, 2018

PubMed: 29483648 | DOI: 10.1038/s41594-018-0033-9

Biological Assemblies

Assembly ID: 1

Details: author_and_software_defined_assembly

Oligomeric State: Monomer

Stoichiometry: A1