Cyclic Peptide DataBank (CPDB)

Summary

PDB ID	7INS Go to RCSB ➚
Title	STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z
Method	X-RAY DIFFRACTION
Resolution	2.00 Å
Release Date	1994-01-31
Authors	Balschmidt, P.; Hansen, F.B.; Dodson, E.; Dodson, G.; Korber, F.
Source Organism	Sus scrofa
Keywords	HORMONE
Molecular Weight	19.34 kDa
Entity Count	Protein: 3, Nucleic Acid: 0, NA Hybrid: 0
Space Group	P 43 21 2
Cell Parameters	a=62.90 Å, b=62.90 Å, c=85.90 Å, α=90.00°, β=90.00°, γ=90.00°
Disulfide Bond	A6-A11;C6-C11;E6-E11
Other Links	Yes
Peptide Chains	A, B, C, D, E, F, G
Peptide Lengths	21, 30, 16

Sequence Information

Chain: A, C, E - INSULIN (CHAIN A) (Length: 21)

1	GIVEQCCTSI CSLYQLENYC N

Chain: B, D, F - INSULIN (CHAIN B) (Length: 30)

1	FVNQHLCGSH LVEALYLVCG ERGFFYTPKA

Chain: G - GENERAL PROTAMINE CHAIN (Length: 16)

1	XXXXXXXXXX XXXXXX

References

Structure of porcine insulin cocrystallized with clupeine Z.

Balschmidt, P., Hansen, F.B., Dodson, E.J., Dodson, G.G., Korber, F.

Acta Crystallogr B, 1991

PubMed: 1772633 | DOI: 10.1107/S010876819100842X

Phenol Stabilizes More Helix in a New Symmetrical Zinc Insulin Hexamer

Derewenda, U., Derewenda, Z., Dodson, E.J., Dodson, G.G., Reynolds, C.D., Smith, G.D., Sparks, C., Swenson, D.

Nature, 1989

The Structure of 2Zn Pig Insulin Crystals at 1.5 Angstroms Resolution

Baker, E.N., Blundell, T.L., Cutfield, J.F., Cutfield, S.M., Dodson, E.J., Dodson, G.G., Hodgkin, D.M.C., Hubbard, R.E., Isaacs, N.W., Reynolds, C.D., Sakabe, K., Sakabe, N., Vijayan, N.M.

Philos Trans R Soc London,ser B, 1988

Ligand Information

ID	Name	Formula	Molecular Weight
CRS	M-CRESOL	C7 H8 O	108.138
ZN	ZINC ION	Zn	65.409
UNL	Unknown ligand	None	None

Biological Assemblies

Assembly ID: 1

Details: author_defined_assembly

Oligomeric State: Hetero 3-mer

Stoichiometry: A1, B1, C1

Assembly ID: 2

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 2-mer

Stoichiometry: A1, B1

Assembly ID: 3

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 2-mer

Stoichiometry: A1, B1

Assembly ID: 4