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Cyclic Peptide DataBank (CPDB)

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8SBD - Cyclic Peptide Structure

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Summary

PDB ID8SBD Go to RCSB ➚
TitleCryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments
MethodELECTRON MICROSCOPY
Resolution3.20 Å
Release Date2023-08-30
AuthorsWang, L.W.; Hall, C.; Uchikawa, E.; Chen, D.L.; Choi, E.; Zhang, X.W.; Bai, X.C.
Source OrganismHomo sapiens
Expression HostEscherichia coli
Gene NamesINS
Keywordsamyloid-like fibril, SIGNALING PROTEIN
Molecular Weight93.08 kDa
Entity CountProtein: 2, Nucleic Acid: 0, NA Hybrid: 0
Disulfide BondP6-P11;O6-O11;N6-N11;M6-M11;L6-L11;K6-K11;J6-J11;I6-I11;H6-H11;G6-G11;F6-F11;E6-E11;D6-D11;C6-C11;B6-B11;A6-A11
Peptide ChainsA, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p
Peptide Lengths30, 21

Sequence Information

Chain: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p - Insulin B chain (Length: 30)

1FVNQHLCGSH LVEALYLVCG ERGFFYTPKT

Chain: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P - Insulin A chain (Length: 21)

1GIVEQCCTSI CSLYQLENYC N

References

Structural basis of insulin fibrillation.

Wang, L., Hall, C.E., Uchikawa, E., Chen, D., Choi, E., Zhang, X., Bai, X.C.

Sci Adv, 2023

PubMed: 37713485 | DOI: 10.1126/sciadv.adi1057

Biological Assemblies

Assembly ID: 1

Details: author_defined_assembly

Oligomeric State: Hetero 32-mer

Stoichiometry: A16, B8, C8

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