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Cyclic Peptide DataBank (CPDB)

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8ZEB - Cyclic Peptide Structure

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Summary

PDB ID8ZEB Go to RCSB ➚
TitleCrystal structure of BCL-XL bound by cp-B6X-4
MethodX-RAY DIFFRACTION
Resolution1.95 Å
R-factorsR-work: 0.181, R-free: 0.226
Release Date2025-01-29
AuthorsSun, X.N.; Liu, J.X.; Wu, D.L.
Source OrganismHomo sapiens, Phage 203
Expression HostEscherichia coli BL21(DE3)
Gene NamesBCL2L, BCL2L1, BCLX
KeywordsBCL-XL, CYCLIC PEPTIDE, APOPTOSIS
Molecular Weight35.95 kDa
Entity CountProtein: 2, Nucleic Acid: 0, NA Hybrid: 0
Space GroupC 2 2 21
Cell Parametersa=64.02 Å, b=97.61 Å, c=93.15 Å, α=90.00°, β=90.00°, γ=90.00°
Other LinksYes
Peptide ChainsC, D
Protein ChainsA, B
Peptide Lengths15
Protein Lengths141

Sequence Information

Chain: A, B - Bcl-2-like protein 1 (Length: 141)

1MSQSNRELVV DFLSYKLSQK GYSWSQPMAA VKQALREAGD EFELRYRRAF SDLTSQLHIT
61PGTAYQSFEQ VVNELFRDGV NWGRIVAFFS FGGALCVESV DKEMQVLVSR IAAWMATYLN
121DHLEPWIQEN GGWDTFVELY G

Chain: C, D - THR-PRO-GLU-TRP-ALA-SER-THR-LEU-ARG-PRO-GLU-(CCS)-(EDN)-(Z7Z)-(PRS) (Length: 15)

1TPEWASTLRP ECXXP

References

Biphenyl-Dihydrothiazole-Cyclized Peptide Libraries for Peptide Lig-and and Drug Discovery

Liu, J.J., Sun, X.N., Zhuang, J., Liu, Z.Y., Xu, C.Y., Wu, D.L., Wu, C.L.

Sci China B Chem, 2025

DOI: 10.1007/s11426-024-2291-x

Biological Assemblies

Assembly ID: 1

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 4-mer

Stoichiometry: A2, B2

Assembly ID: 2

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 2-mer

Stoichiometry: A1, B1

Assembly ID: 3

Details: author_and_software_defined_assembly

Oligomeric State: Hetero 2-mer

Stoichiometry: A1, B1

3D Structure Visualization