The focus of my research is the development and application of new technology and methods in cryo-electron microscopy (cryo-EM). More specifically, I am interested in the development of techniques involved in high-throughput automated cryo-EM imaging as well as approaches to improve the performance of electron microscopes.

My major work is providing the facility and technology support for macromolecular crystallography research. The facility services included providing all kinds of the automatic devices from liquid handing to crystal screening and optimization, also including data collection and structural solving. The technology support included the crystallography consulting and project research for non-crystallography lab.

Our primary research interests are focused on characterizing structure and dynamics of non-coding RNAs and intrinsically disordered proteins using solution NMR spectroscopy and computational approaches such as MD simulations. We aim to develop novel NMR techniques, labeling methods, and computational tools to study three-dimensional structure and conformational switch of large non-coding RNAs and ribonucleoproteins, which pose a significant challenge to existing methods. We are also interested in reconstructing conformational motion of highly flexible biomolecules, as well as ensemble-based virtual drug screening.

We focus on the computing biology and tuning for the HPC cluster in the biological fields. We are also interested in the high performance parallel computing technology in the CryoEM image processing pipeline

The preparation, purification and identification of protein is the basis of all protein scientific research. the Core Facility for Biomolecule Preparation and Characterization at Technology Center for Protein Science, Tsinghua University have the scale effect since foundation, which can give full support to the research on protein structure and function. We provide four kinds of expression systems such as: E. Coli, Yeast, Insect cell and Mammalian cell suspended system to researchers from universities, research institutes, small biological companies and so on. We can also provide the protein related services, including molecular cloning, expression and purification, characterization，analysis of interaction，Screening of small molecule compounds and a series of related research.