The Beijing Frontier Research Center for Biological Structure (FRCBS), established by the Beijing Municipal Science and Technology Commission in 2018, is a leading research institution based at Tsinghua University. The center's origins trace back to the Center for Structural Biology of Tsinghua University (2011–2015) and the Beijing Advanced Innovation Center for Structural Biology (2015–2019).

The center boasts a team of 29 Core Principal Investigators (PIs) and 20 Cooperate Principal Investigators (Co-PIs), along with over 400 undergraduates, graduates, and postdoctoral fellows. The research conducted at the center spans various cutting-edge areas of modern structural biology. Key focus areas include the study of the structure and function of vital biomolecules such as biological macromolecular machines, disease-related membrane proteins, and tumor suppressors, as well as the development of new biological structural techniques and methodologies. Aiming to be at the forefront of international research, the center leverages its strong disciplinary advantages to achieve significant breakthroughs and forward-looking results. Since 2015, the center has published 120 papers in top-tier academic journals (Nature, Science, Cell) as first and corresponding authors. With the rapid advancement of cryo-electron microscopy technology, structural biology has made remarkable progress, with Tsinghua University standing out for its increasing international status and influence. This field is now among the few in basic research where China leads globally.

As a new type of research institution driving high-quality development in Beijing, the center capitalizes on its academic strengths to promote structural biology as a key interdisciplinary field. It focuses on several cutting-edge areas, including the development of next-generation cryo-electron microscopy devices and core technologies, AI-driven new biological structure technologies, innovative drug discovery and development based on biological structures, and the discovery and establishment of frontier knowledge in biological structures. The center is dedicated to tackling critical core technologies and solving fundamental scientific challenges from the ground up.