Hang Shi

Main Research Fields

Hang Shi’s laboratory combines structural and functional approaches to investigate, from the molecular perspective, the production, metabolism, function and related regulatory mechanisms of intracellular RNA, and develop biological and medical tools. In addition, we also apply multiple structural biology methods to understand the formation and function of cellular organelles (for instance, cillia).

Selected Publications

1. Shao W, Yang J, He M, Yu XY, Lee CH, Yang Z, Joyner AL, Anderson KV, Zhang J, Tsou MB, Shi H*, Shi SH*.(2020)Centrosome anchoring regulates progenitor properties and cortical formation.Nature, 580(7801):106-112.

2.Hao Q, Zhang B, Yuan K, Shi H*, Blobel G.(2018)Electron microscopy of Chaetomium pom152 shows the assembly of ten-bead string. Cell Discov.,4:56.

3.Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G*. (2016) Structure of Niemann-Pick disease protein 1. Proc. Natl. Acad. Sci. U. S. A., 113(29): 8212-8217.

4.Singh N, Blobel G, Shi H*. (2015) Hooking She3p onto She2p for myosin-mediated cytoplasmic mRNA transport. Proc. Natl. Acad. Sci. U. S. A., 112(1):142-147.

5.Shi H *, Singh N, Esselborn F, Blobel G. (2014) structure of a myosin•adaptor complex and pairing by cargo. Proc. Natl. Acad. Sci. U. S. A. 111(2):1082-1090.