Dong Li_Beijing Frontier Research Center for Biological Structure

Contact information

Email：li-dong@tsinghua.edu.cn

Dong Li 博士

Winner for Explore Prize

Resume

2002-2006 Department of Optical Engineering, Zhejiang University B.S.

2006-2011 Department of Electronic & Computer Engineering, Hong Kong University of Science & Technology Ph.D.

2011-2015 Janelia Research Campus, Howard Hughes Medical Institute Postdoc.

2015-2024 Institute of Biophysics, Chinese Academy of Science Principal Investigator

2024-Present School of Life Sciences, Tsinghua University Professor

Main Research Fields

We focus on developing novel optical imaging methods, which enable us to measure and study the biological processes with unprecedented precision, such as structures and dynamics of molecular assemblies in living biological systems, interactions between molecules, and behavior of individual molecules, etc. We are greatly enjoying working at the interface of several disciplines, where light, algorithm and biology catalyze each other.

Selected Publications

1. Qiao C^#, Chen H^#, Wang R^#, Jiang T, Wang Y, Li D*. Deep learning-based optical aberration estimation enables offline digital adaptive optics and super-resolution imaging. Photonics Research, 2024 Mar; 12(3):474-484. Cover article.

2. Qiao C^#, Zeng Y^#, Meng Q^#, Chen X^#, Chen H, Jiang T, Wei R, Guo J, Fu W, Lu H, Li D, Wang Y, Qiao H, Wu J, Li D*, Dai Q*. Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy. Nature Communications, 2024 May; 15(1):4180.

3. Qiao C^#, Li D^#, Liu Y^#, Zhang S^#, Liu K, Liu C, Guo Y, Jiang T, Fang C, Li N, Zeng Y, He K, Zhu X, Lippincott-Schwartz J*, Dai Q*, Li D*. Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes. Nature Biotechnology, 2023 Mar; 41(3):367-377. Cover article.

4. Gong B^#, Guo Y^#, Ding S, Liu X, Meng A, Li D*, Jia S*, A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. Nature Cell Biology, 2021 Jul; 23(7):782-795.

5. Xu G^#, Liu C^#, Zhou S^#, Li Q, Feng Y, Sun P, Feng H, Gao Y, Zhu J, Luo X, Zhan Q, Liu S, Zhu S, Deng H*, Li D*, Gao P*. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. Molecular Cell, 2021 Jul 1;81(13):2823-2837.

6. Li D^#, Colin-York H^#, Barbieri L^#, Javanmardi Y^#, Guo Y, Korobchevskaya K, Moeendarbary E*, Li D*, Fritzsche M*. Astigmatic traction force microscopy (aTFM). Nature Communications, 2021 Apr 12; 12(1):2168.

7. Qiao C^#, Li D^#, Guo Y^#, Liu C^#, Jiang T, Dai Q*, Li D*. Evaluation and development of deep neural networks for image super-resolution in optical microscopy. Nature Methods, 2021 Feb;18(2):194-202.

8. Wang X^#*, Liu C^#, Zhang S^#, Yan H, Zhang L, Jiang A, Liu Y, Feng Y, Li D, Guo Y, Hu X, Lin Y, Bu P, Li D*. N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles. Developmental Cell, 2021 Mar 8;56(5):702-715.

9. Qin J, Guo Y, Xue B, Shi P, Chen Y, Su Q, Hao H, Zhao S, Wu C, Yu L, Li D*, Sun Y*. ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. Nature Communications, 2020 Sep 8;11(1):4471.

10. Guo Y ^#, Li D^#, Zhang S, Yang Y, Liu JJ, Wang X, Liu C, Milkie DE, Moore RP, Tulu US, Kiehart DP, Hu J, Lippincott-Schwartz J*, Betzig E*, Li D*.Visualizing intracellular organelle and cytoskeletal interactions at nanoscale resolution on millisecond timescales. Cell, 2018 Nov 15;175(5):1430-1442.

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