Pilong Li Ph.D.

Associate Professor | 2021 WuXi AppTec Life Science and Chemistry Awards Scholar | 2021 National Natural Science Foundation of China for Distinguished Young Scholar |
2019 Bayer Investigator

Main Research Fields

My lab is dedicated to elucidate the roles of liquid-liquid phase separation (LLPS) in many biological pathways and also the roles of aberrant LLPS in various diseases including cancer and neurodegerative diseases. We are developing LLPS-based biochemical assays for investigation molecular interactions in vitro and in vivo.

Selected Publications

1. Li, P.*, Banjade, S.*, Cheng, H.*, et al. and Rosen, M. K. (2012). Phase transitions in the assembly of multivalent signalling proteins. Nature. 483, 336-340.

2. Sun, D., Wu, R., Zheng, J., Li, P.#, and Yu, L.#. (2018) Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation. Cell Research 28, 405-415.

3. Zhao, S., Cheng, L., Gao, Y., Zhang, B., Zheng, X., Wang, L., Li, P.#, Sun, Q.#, and Li, H.#. Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. (2019) Cell Research 29, 54-66.

4. Fang, X., Wang, L., et al., Li, P.#, and Dean, C.#. Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes. (Nature, Accepted).

5. Wang, L., Gao, Y., Zheng, X., et al., Li, H.#, and Li, P.#. (Molecular Cell, major revision).

6. Zuo, L., Zhang, G., et al., Li, P.#, and Qi, Z.#. (Submitted, March 2019)

7.Gao, Y., Pei, G., Li, D.., et al., and Li, P.#. (Submitted, April 2019)

*: Co-first author;     #: Corresponding authors