Jiawei Wang Ph.D.

Associate Professor

Main Research Fields

Mannose transport complex (man-PTS) is an important member of bacterial phosphotransferase system (PTS), which is responsible for the uptake of glucose, mannose and various sugars. In addition, man-PTS has been reported as a target of related bacteriocins, which participate in or mediate the bactericidal effect. Our team has analyzed the structure of man-PTS from Escherichia coli, the target of bacteriocin. In the future, we will continue to study the bactericidal mechanism of bacteriocins and man-PTS by means of crystallography and cryo- electron microscopy, and provide ideas for the design and development of new antibacterial drugs and food additives. At the same time, we explore the difficult problems in the process of structural analysis and develop new structural analysis methods.

Selected Publications

1. Zhou N, Wang H*, Wang J*. (2017) EMBuilder: A Template Matching-based Automatic Model-building Program for High-resolution Cryo-Electron Microscopy Maps. Scientific Reports, 7:2664.

2. Bao Z, Qi X, Hong S, Xu K, He F, Zhang M, Chen J, Chao D, Zhao W, Li D, Wang J*, Zhang P*. (2017) Structure and mechanism of a group-I cobalt energy coupling

factor transporter. Cell Research, 27:675-687.

3. Yang H, Wang J, Liu M, Chen X, Huang M, Tan D, Dong MQ, Wong CC, Wang J*, Xu Y*, Wang HW*. (2016) 4.4 A Resolution Cryo-EM structure of human mTOR

Complex 1. Protein & Cell, 7:878-887.

4. Wang J*, Chai J, Wang H. (2016) Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA. The FEBS Journal, 283:1631-5.

5. Wang J, Wang W, Song W, Han Z, Zhang H, Chai J*, Wang H*, Wang J*. (2015) An improved method for phasing crystal structures with low non-crystallographic

symmetry using cryo-electron microscopy data. Protein & Cell, 6:919-23.

6. Song W, Wang J, Han Z, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J*, Wang HW*, Chai J*. (2015) Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature Structural & Molecular Biology, 22:782-7.

7. Luo P, Yu X, Wang W, Fan S, Li X, Wang J*. (2015) Crystal structure of a phosphorylation-coupled vitamin C transporter. Nature Structural & Molecular Biology,

22:238-41.