Ye Xiang Ph.D.

Associate Professor | Outstanding Young Talent of National Science Foundation For China

Main Research Fields

Our research group is interested in the molecular mechanisms of the assembly and function of complex molecular machineries. We use cryo-electron microscopy and x-ray crystallography for our studies.

Selected Publications

1. Gui M, Song WF, Zhou HX, Xu JW, Chen SL, Xiang Y* and Wang XQ*. （2017）Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a

prerequisite conformational state for receptor binding. Cell Res, 27(1):119-129.

2. Gui M, Liu X, Guo DY, Zhang Z, Yin CC*, Chen Y*, Xiang Y*. （2017）Electron Microscopy Studies of the Coronavirus Ribonucleoprotein Complex. Protein Cell,

8(3):219-224.

3. Xu J, Gui M, Wang D, Xiang Y*. （2016）The bacteriophage ϕ29 tail possesses a pore-forming loop for cell membrane penetration. Nature, 534(7608):544-7.

4. Misasi J, Gilman MS, Kanekiyo M, Gui M, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS,

Xiang Y*, Sullivan NJ*, McLellan JS. （2016）Structural and molecular basis for Ebola virus neutralization by protective human antibodies. Science, 351(6279):1343-6.

5. Zhang Q, Gui M, Niu X, He S, Wang R, Feng Y, Kroeker A, Zuo Y, Wang H, Wang Y, Li J, Li C, Shi Y, Shi X, Gao GF, Xiang Y, Qiu X, Chen L, Zhang L. （2016）Potent

neutralizing monoclonal antibodies against Ebola virus infection. Sci Rep, 6:25856.

6. Sun L, Zhang X, Gao S, Rao PA, Padilla-Sanchez V, Chen Z, Sun S, Xiang Y, Subramaniam S, Rao VB Rossmann MG. (2015) Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat Commun, 6:7548.

7. Wang Z, Wu D, Liu Y, Xia X, Gong W, Qiu Y, Yang J, Zheng Y, Li J, Wang YF, Xiang Y, Hu Y, Zhou X. (2015) Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling. Sci Adv, 1(9):e1500228.

8. Zhu DY, Wang L, Shang G, Liu X, Zhu J, Wang L, Lu DF, Kan B, Zhang JR, Xiang Y*. (2014) Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals

cyclase activity regulation by folates. Mol Cell, 55(6):931-937.

9. Liu Y, Zhang F, Liu J, Xiao X, Zhang S, Qin C, Xiang Y, Wang P, Cheng G. (2014) Transmission-blocking antibodies against mosquito C-type lectins for dengue

prevention. PLoS Pathog, 10(2):e1003931.

10. Sun S, Xiang Y, Akahata W, Holdaway H, Pal P, Zhang X, Diamond MS, Nabel GJ, Rossmann MG.（2013）Structural analyses at pseudo atomic resolution of

Chikungunya virus and antibodies show mechanisms of neutralization. Elife, 2:e00435.