Maojun Yang_Beijing Frontier Research Center for Biological Structure

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Email：maojunyang@tsinghua.edu.cn

Maojun Yang Ph.D.

Professor | Outstanding Young Talent of the National Science Foundation for China

Resume

1995-1999College of Life Sciences, Jilin University B.S.

1999-2003Institute of Basic Medical Sciences, Peking Union Medical College Ph.D.

2004-2008University of Texas Southwestern Medical Center at Dallas Postdoc.

2008-2013School of Life Sciences, Tsinghua University Special researcher

2013-PresentSchool of Life Sciences, Tsinghua University Professor

Main Research Fields

We mainly work on structural biology combined with cell and molecular biology, together with biochemistry as the research means to engage in the research on the structure and function of cell induced external signals and proteins related to cell energy metabolism, and carry out drug design and clinical application research based on the high-resolution structure of these biological macromolecules.

Selected Publications

1. Gu et.al. The coupling mechanism of mammalian mitochondrial complex I. Nat Struct Mol Biol. 2022 Feb;29(2):172-182.
2. Wang et.al. Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science. 2021 Oct 14:eabl4546.
3. Gu J, Zhang L, Zong S, Guo R,Liu T, Yi J, Wang P, Zhuo W, Yang M*.(2019)Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1. Science, 364(6445):1068-1075.
4. Zong S, Wu M, Gu J, Liu T, Guo R, Yang M*.*(2018) Structure of the intact 14-subunit human cytochrome c oxidase. Cell Res., 28(10):1026-1034.
5. Zong S, Gu J, Liu T, Guo R, Wu M, Yang M*.(2018)UQCRFS1N assembles mitochondrial respiratory complex-III into an asymmetric 21-subunit dimer. Protein Cell, 9(6):586-591.
6. Guo R, Zong S, Wu M, Gu J, Yang M*. (2017)Architecture of human mitochondrial respiratory megacomplex I2III2IV2. Cell, 170(6):1247-1257.
7. Wu M, Gu J, Guo R, Huang Y, Yang M*.(2016) Structure of mammalian respiratory supercomplex I1III2IV1. Cell, 167(6):1598-1609.
8. Gu J, Wu M, Guo R, Yan K, Lei J, Gao N*, Yang M*. (2016)The architecture of the mammalian respirasome. Nature, 537(7622):639-643. (Article)
9. Ge J, Li W, Zhao Q, Li N, Cheng M, Zhi P, Li R, Gao N*, Xiao B*, Yang M*.(2015) Architecture of the Mammalian Mechanosensitive Piezo1 Channel. Nature, 527(7576):64-69. (Article)
10. Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y*, Yang M*.(2012) Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance. Proc Natl Acad Sci U S A., 109(44):18180-5.

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