Xiangyu Liu_Beijing Frontier Research Center for Biological Structure

Contact information

Email：Liu_xy@mail.tsinghua.edu.cn

Xiangyu Liu Ph.D.

Associate Professor

Resume

2000-2004Peking University B.S.

2004-2011Peking University Ph. D.

2008-2010Aarhus University Denmark. Exchange Ph.D. student

2011-2013School of Life Sciences, Peking University Postdoc.

2013-2017School of Medicine, Tsinghua University Postdoc.

2017-2019School of Medicine, Tsinghua University Assistant Researcher

2019-presentSchool of Pharmaceutical Science, Tsinghua University Assistant Professor

Main Research Fields

G protein coupled receptors (GPCRs) are a group of membrane receptors with seven transmembrane helices. They sense various signals from outside of the cells, transfer the signals to intracellular pathways and modulate cellular responses to environment. The ligands of GPCRs include odorants, hormones, neurotransmitters, chemokines, et al. GPCRs are targets of approximately 30% commercially available medicines. Structural studies on GPCRs have made great progress in the past decade, however the structural basis of receptor-G protein selectivity and the molecular mechanism of biased signaling remain unclear. My lab aims to elucidate structures of disease related GPCRs and structure based drug development. We also aim to develop novel methods to find GPCR drugs.

Selected Publications

1. Xinyu Xu#, Jonas Kaindl#, Mary J. Clark#, Harald Hübner, Kunio Hirata, Roger K. Sunahara*, Peter Gmeiner*, Brian K. Kobilka, Xiangyu Liu*. (2021) Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR. Cell Research. 31, 569-579.

2. Xiangyu Liu#, Jonas Kaindl#, Magdalena Korczynska, Anne Stößel, Daniela Dengler, Markus Stanek, Harald Hübner, Jake Mahoney, Mary J. Clark, Rachel Ann Matt, Xinyu Xu, Kunio Hirata, Brian K. Shoichet, Roger K. Sunahara*, Brian K. Kobilka*, Peter Gmeiner*. (2020) Discovery of an allosteric modulator binding to a conformational hub in the β2 adrenergic receptor. Nature Chemical Biology. 16, 749-755.

3. Xiangyu Liu#, Ali Masoudi#, Alem W. Kahsai#, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, Kunio Hirata, Rishabh K. Simhal, Allison M. Schwalb, Paula K. Rambarat, Seungkirl Ahn, Robert J. Lefkowitz*, Brian Kobilka*. (2019) Mechanism of β2AR regulation by an intracellular positive allosteric modulator.Science, 364 (6447):1283-1287.

4. Xiangyu Liu#*,Xinyu Xu#, Daniel Hilger#, Philipp Aschauer, Johanna K.S. Tiemann, Yang Du, Hongtao Liu, Kunio Hirata, Xiaoou Sun, Ramon Guixà-González, Jesper M. Mathiesen, Peter W. Hildebrand, Brian Kobilka*.(2019) Structural insights into the process of GPCR-G protein complex formation.Cell,177(5):1243-1251.

5. Hongtao Liu#, Josefa Hofmann#, Inbar Fish#, Benjamin Schaake, Katrin Eitel, Amelie Bartuschat, Jonas Kaindl, Hannelore Rampp, Ashutosh Banerjee, Harald Hübner, Mary J. Clark, Sandra G. Vincent , John T. Fisher, Markus R. Heinrich, Kunio Hirata, Xiangyu Liu*, Roger K. Sunahara, Brian K. Shoichet*, Brian K. Kobilka*, Peter Gmeiner*. (2018)Structure-guided development of selective muscarinic M3 acetylcholine receptor antagonists.PNAS.,115(47):12046-12050.

6. Xiangyu Liu#,Seungkirl Ahn#, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, Ali Masoudi, William I. Weis, Ron O. Dror, Xin Chen, Robert J. Lefkowitz*, Brian K. Kobilka*. (2017) Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature, 548:480-484.

7. Yi-He Huang#, Xiangyu Liu#, Xiao-Xia Du, Zheng-Fan Jiang, Xiao-Dong Su. (2012) The Structural Basis for the Sensing and Binding of Cyclic di-GMP by STING. Nature Structural & Molecular Biology,19: 728–730.

8. Pontus Gourdon#, Xiang-Yu Liu#, Tina Skjørringe, J. Preben Morth, Lisbeth Birk Møller*, Bjørn Panyella Pedersen, Poul Nissen*. (2011)Crystal structure of a copper-transporting PIB-type ATPase. Nature, 475: 59-64.

About us

Faculty

Research

News&Events

Meeting

Download

Contact Us