Chuangye Yan Ph.D.

Assistant Professor

Main Research Fields

1. Methods Development in X-ray crystallography and cryo-electron microscopy.

2. Investigation of the structure and function of important membrane proteins.

3. Studies on the Structure and Function of Spliceosomes in Eukaryotic Cells and the Mechanism of Pre-mRNA Splicing.

Selected Publications

1. Yan C#, Wan R#, Shi Y. (2019). Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome. Cold Spring Harb Perspect Biol, doi: 10.1101/cshperspect.a032409.
2. Zhang X#, Zhan X#, Yan C#*, Zhang W, Lei J, Shi Y. (2019). Structures of the human spliceosomes before and after release of the ligated exon. Cell Res, 29(4): 274-285.
3. Bai R#, Wan R#, Yan C#, Lei J, Shi Y. (2018). Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science, 360(6396): 1423-1429. 
4. Zhan X#, Yan C#*, Zhang X#, Lei J, Shi Y. (2018). Structure of a human catalytic step I spliceosome. Science,3 59(6375): 537-545.
5. Zhang X#, Yan C#, Hang J#, Finci LI, Lei J, Shi Y. (2017). An Atomic Structure of the Human Spliceosome. Cell, 169(5): 918-929.
6.  Yan C#, Wan R#, Bai R#, Huang G, Shi Y. (2017) Structure of a yeast step II catalytically activated spliceosome. Science, 355(6321): 149-155.
7. Yan C#, Wan R#, Bai R#, Huang G, Shi Y. (2016). Structure of a yeast activated spliceosome at 3.5 A resolution. Science ,353, 904-911
8. Yan C#, Hang J#, Wan R#, Huang M, Wong CC, and Shi Y. (2015). Structure of a yeast spliceosome at 3.6-angstrom resolution. Science , 349, 1182-1191, doi:10.1126/science.aac7629 (2015).
9. Bai XC#, Yan C#, Yang G#, Lu P, Ma D, Sun L, Zhou R, Scheres SHW, Shi Y. (2015). An atomic structure of human gamma-secretase. Nature , 525, 212-217.
10. Deng D#, Yan C#, Pan X#, Mahfouz M, Wang J, Zhu J.K, Shi Y, Yan N. (2012a) Structural basis for sequence-specific recognition of DNA by TAL effectors. Science ,335: 720-723.