Heng Zhou Ph.D.

2020 Shuimu Scholar, Tsinghua University
2020 Advanced Innovation Fellow, Beijing Advanced Innovation Center for Structural Biology
2020 Outstanding Graduate of Tsinghua University
2020 Outstanding Dissertation of Tsinghua University
2019 National Scholarship
2018 Innovation Scholarship, Beijing Advanced Innovation Center for Structural Biology
2018 National Scholarship

Main Research Fields

1. Methodology investigation of micro-crystal electron diffraction.

2. Structural investigation of mechanosensitive Piezo channels.

Selected Publications

1. Jie Geng*, Wenhao Liu*, Heng Zhou*, Tingxin Zhang*, Li Wang*, Mingmin Zhang, Yiran Li, Bo Shen, Xueming Li, Bailong Xiao (2020). A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel. Neuron 106, 438–451. (* co-first author)

2. Heng Zhou*, Feng Luo*, Zhipu Luo*, Dan Li, Cong Liu, Xueming Li (2019). Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules. Analytical Chemistry 91, 10996-11003. (* co-first author)

3. Heng Zhou*, Zhipu Luo*, Xueming Li (2019). Using focus ion beam to prepare crystal lamella for electron diffraction. Journal of Structural Biology 205, 59-64. (* co-first author)

4. Li Wang*, Heng Zhou*, Mingmin Zhang*, Wenhao Liu*, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li, Bailong Xiao (2019). Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature 573, 225–229. (* co-first author)

5. Qiancheng Zhao*, Heng Zhou*, Shaopeng Chi*, Yanfeng Wang*, Jianhua Wang, Jie Geng, Kun Wu, Wenhao Liu, Tingxin Zhang, Meng-Qiu Dong, Jiawei Wang, Xueming Li, Bailong Xiao (2018). Structure and mechanogating mechanism of the Piezo1 channel. Nature 554, 487–492. (* co-first author)

6. Feng Luo*, Xinrui Gui*, Heng Zhou*, Jinge Gu, Yichen Li, Xiangyu Liu, Minglei Zhao, Dan Li, Xueming Li, Cong Liu (2018). Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nature Structural & Molecular Biology 25, 341–346. (* co-first author)