Qingyun Zheng Ph.D.

2020 National Scholarships for Graduate Students
2020 Excellent Ph.D Scholarship, Beijing Advanced Innovation Center for Structural Biology
2019 Talent Scholarship by Friends of Tsinghua University, Yangtze River Delta International R&D Community,
2018 Poster Prize in Chinese International Peptide Symposium
2016 Excellent Graduation Thesis in Department of Chemistry

Main Research Fields

My major field is structual studies of the ubiquitin ligases and the protein machine p97, which play critical roles in writing and reading the ubiquitin code in cellular biology, respectively. My research feature is to obtain structurally precise protein samples with defined modifications through developing protein chemical synthesis technology. With these special protein samples in hand, I aim to capture the different and transient conformational intermediates for these ubiquitin functional molecular machines, and elucidate the detailed molecular mechanism during the whole catalytic process.

Selected Publications

1. Yuanyuan Yu*, Qingyun Zheng*, Satchal K. Erramilli*, Man Pan*, Seongjin Park, Yuan Xie, Jingxian Li, Jingyi Fei, Anthony A. Kossiakoff, Lei Liu, Minglei Zhao. (2021). K29-linked Ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nature Chemical Biology. (Accepted) (* co-first authors)

2. Man Pan*, Qingyun Zheng*, Yuanyuan Yu*, Huasong Ai, Yuan Xie, Xin Zeng, Chu Wang, Lei Liu, Minglei Zhao. (2021). Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nature Communications. 12, 121-133. (* co-first authors)

3. Qingyun Zheng*, Tian Wang*, Guo-Chao Chu*, Chong Zuo, Rui Zhao, Xin Sui, Linzhi Ye, Yuanyuan Yu, Jingnan Chen, Xiangwei Wu, Wenhao Zhang, Haiteng Deng, Jing Shi, Man Pan, Yi-Ming Li, Lei Liu. (2020). An E1-Catalyzed Chemoenzymatic Strategy to Isopeptide-N-Ethylated Deubiquitylase-Resistant Ubiquitin Probes. Angewandte Chemie International Edition. 59, 13496-13501.

4. Man Pan*, Qingyun Zheng*, Shan Ding*, Lujia Zhang*, Qian Qu, Tian Wang, Danning Hong, Yujing Ren, Lujun Liang, Chunlai Chen, Ziqing Mei, Lei Liu.  (2019). Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angewandte Chemie International Edition. 58, 2627-2631. (* co-first authors)