李元元 博士

2018 结构生物学高精尖创新中心卓越青年科学家
2017 北京市科技新星
2017 中国科协青年人才托举工程
2016 清华大学结构生物学高精尖创新中心卓越学者
2016 国际JBC/Herb Tabor青年研究学者奖

主要科研领域与方向

1.表观遗传调控与人类健康疾病的分子结构机理研究

2.基于结构的重要表观遗传调控因子(如YEATS结构域蛋白)早期药物发现

代表性论文

1. Li X, Li XM, Jiang Y, Liu Z, Cui Y, Fung KY, van der Beelen She, Tian G, Wang L, Shi X, Allis CD, Li H, Li Y*, Li XD* (2018) Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking. Nat Chem Biol 14:1140-1149 (#co-corresponding author)

2. Wan L#, Wen H#, Li Y#, Lvu J, Xi Y, Hoshii T, Joseph J, Wang X, Loh Y, Erb MA, Souza AL, Bradner JE, Shen L, Li W, Li H, Allis CD*, Armstrong SA*, and Shi X#* (2017) ENL links histone acetylation to oncogenic gene expression in AML. Nature 543, 265-269 (#co-first author)

3. Li Y#, Sabari BR#, Panchenko T#, Wen H, Zhao D, Guan H, Wan L, Tang Z, Zhao Y, Roeder R. Shi X, Allis CD*, and Li H* (2016) Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain. Mol Cell 62:181-193 (#co-first author)

4. Li Y#, Wen H#, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SYR, Li W, Li H*, and Shi X* (2014) AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell 159:558-571 (#co-first author)

5. Wen H#*, Li Y#, Xi Y#, Jiang S, Stratton S, Peng D, Tanaka K, Ren Y, Xia Z, Wu J, Li B, Barton MC, Li W*, Li H*, and Shi X* (2014) ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Nature 507, 263-268 (#co-first author)