俞立 博士

教授
国家杰出青年基金获得者

主要科研领域与方向

综合细胞生物学，遗传学，生物化学，分子生物学等研究方法，以不同模式生物为模型研究新细胞器迁移体（Migrasome）的机制与功能。

代表性论文

1.   Dong Jiang, Lin Jiao, Qing Li, Renxiang Xie, Haohao Jia, Shihui Wang, Yining Chen, Siyuan Liu, Dandan Huang, Jiajia Zheng, Wenhao Song, Ying Li, Jianfeng Chen, Jinsong Li, Binwu Ying, Li Yu^# (2024). Neutrophil-derived migrasomes are an essential part of the coagulation system. Nat Cell Biol. (on line)

2.   Haifeng Jiao^#, Xiaopeng Li, Ying Li, Yuting Guo, Xiaoyu Hu, Takami Sho, Yiqun Luo, Jinyu Wang, Huizhen Cao, Wanqing Du, Dong Li, Li Yu^# (2024). Localized, highly efficient secretion of signaling proteins by migrasomes. Cell Res. (on line)

3.   Haisha Liang, Xinyu Ma, Yuanyuan Zhang, Yuheng Liu, Nan Liu, Weiying Zhang, Jianhui Chen, Boqi Liu, Wanqing Du, Xiaohui Liu and Li Yu^# (2023). The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells. Nat Cell Biol; 25(8):1173-1184.

4.   Tianlun Ding, Jinyao Ji, Weiying Zhang, Yuheng Liu, Boqi Liu, Yiyang Han, Chunlai Chen, Li Yu^# (2023). The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation. Cell Res, 33(8):617-627.

5.   Cuifang Zhang, Tianqi Li, Shuyao Yin, Mingyi Gao, Helen He, Ying Li, Dong Jiang, Minghui Shi, Jianbin Wang and Li Yu^# (2022). Monocytes deposit migrasosomes to promote embryonic angigogenesis. Nat Cell Biol, 24(12):1726-1738. (Cover Story)

6.   Yuwei Huang, Xing Zhang, Hong-Wei Wang, Li Yu^# (2022). Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair. Nat Cell Biol, 24:825-832.

7.   Haifeng Jiao*, Dong Jiang*, Xiaoyu Hu, Wanqing Du, Liangliang Ji, Yuzhuo Yang, Xiaopeng Li, Takami Sho, Xuan Wang, Ying Li, Yu-Ting Wu, Yau-Huei Wei, Xiaoyu Hu, and Li Yu^# (2021). Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell, 184:2896-2910.

8.   DongJiang*, Zheng Jiang*, Di Lu, Xuan Wang, Haisha Liang, Junfeng Zhang, Yaping Meng, Ying Li, Danni Wu, Yuwei Huang, Yuling Chen, Haiteng Deng, Qing Wu, Jingwei Xiong, Anming Meng^# and Li Yu^# (2019). Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol, 21(8):966-977. (Cover Story)

9.   Yuwei Huang*, Ben Zucker*, Shaojin Zhang*, Sharon Elias, Yun Zhu, Hui Chen, Tianlun Ding, Ying Li, Yujie Sun, Jizhong Lou, Michael M.Kozlov^# and Li Yu^# (2019). Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol, 21(8):991-1002. (Cover Story)

10. Liang Ma*, Ying Li*, Junya Peng*, Danni Wu, Xiaoxin Zhao, Yitong Cui, Lilian Chen, Xiaojun Yan, Yanan Du, Li Yu^# (2015). Discovery of the migrasome, an organelle mediates release of cytoplasmic contents during cell migration. Cell Res, 25(1):24-38. (Cover Story)