陈帅嘉彬 博士

主要科研领域与方向

核孔复合体（NPC）相关研究，重点关注核质转运过程，以核糖体大亚基的运输为代表，并致力于探索原位核孔复合体的结构与功能。研究结合冷冻电镜（cryo-EM）、分子生物学和生物信息学等多学科方法，解析不同货物在核孔通道中的不同构象状态及其与核转运受体的相互作用。此外，关注人工智能（AI）在冷冻电镜数据处理中的应用，特别是在原位结构解析相关算法方面，并参与开发用于图像去噪和结构解析的AI算法，以突破原位蛋白质结构解析的分辨率极限，提高大规模数据处理的效率。

代表性论文

1.     Li Zongqiang*, Chen Shuaijiabin*, Zhao Liang*, Huang Guoqiang*, Pi Xiong, Sun Shan, Wang Peiyi and Sui Sen-Fang (2022). Near atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Cell Res 32, 437-450. (SCI, IF= 46.351, * co-first author).

2.     Li Zongqiang*, Chen Shuaijiabin*, Zhao Liang, Huang Guoqiang, Xu Huiqin, Wang Peiyi, Gao Ning and Sui Sen-Fang (2023). Nuclear export of pre-60S particles through the nuclear pore complex. Nature 18, 411-418. (SCI, IF= 69.504, * co-first author).

3.     Wu Jianghao*, Chen Shuaijiabin*, Wang Chao, Lin Weijun, Huang Chao, Fan Chengxu, Han Dexian, Lu Dandan, Xu Xiumei, Sui Sen-Fang, Zhang Lixin (2023). Regulatory dynamics of the higher-plant PSI-LHCI supercomplex during state transitions. Mol Plant 16, 1937-1950. (SCI, IF= 21.949, * co-first author).

4.     Liang, Zhou, Ziwen Tang, Changjian Zhu, Feng Li, Chen Shuaijiabin, Xu Han, Ruilin Zheng, Xinrong Hu, Ruoni Lin, Qiaoqiao Pei, Changjun Yin, Ji Wang, Ce Tang, Nan Cao, Jincun Zhao, Rong Wang, Xiaoyan Li, Ning Luo, Qiong Wen, Jianwen Yu, Jianbo Li, Xi Xia, Xunhua Zheng, Xin Wang, Naya Huang, Zhong Zhong, Chengqiang Mo, Peisong Chen, Yating Wang, Jinjin Fan, Yun Guo, Haojie Zhong, Jiaqi Liu, Zhenwei Peng, Haiping Mao, Guo-Ping Shi, Joseph V. Bonventre, Wei Chen, and Yi Zhou (2024). Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression. Immunity 57, 1306-1323.e8. (SCI, IF=25.5).

5.     Zhao Gexin, Fang Xinyan, Bu Guolong, Chen Shuaijiabin, Sun Cong, Ting Li, Chu Xie, Yu Wang, Li Shuxin, Ning Meng, Feng Guokai, Qian Zhong, Kong Xiangwei, Zheng Liu, and Zeng Musheng (2024). Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection. Cell Reports Medicine 5, 2666-3791. (SCI, IF=11.97).