教授
中国科学院院士
1964-1970清华大学精密仪器系 学士
1978-1981清华大学工程物理系 硕士
1985-1988慕尼黑工业大学生物物理所 博士
1989-1991清华大学生物科学与技术系 副教授
1991-至今清华大学生命科学学院 教授
利用冷冻电子显微学，结合生物化学、生物物理学和细胞生物学等技术手段，研究：
1. 蛋白质复合体、复杂蛋白质机器和膜蛋白的结构、功能与工作机制；
2. 囊泡运输中的分子机制，蛋白质与膜脂的相互作用，生物膜与重大疾病的关系。
1. Zongqiang Li, Shuaijiabin Chen, Liang Zhao, Guoqiang Huang, Huiqin Xu, Xiaoyun Yang, Peiyi Wang, Ning Gao, Sen-Fang Sui* (2023). Nuclear export of pre-60S particles through the nuclear pore complex. Nature, 618(7964):411-418.
2. Xin You, Xing Zhang, Jing Cheng, Yanan Xiao, Jianfei Ma, Shan Sun, Xinzheng Zhang*, Hong-Wei Wang*, Sen-Fang Sui* (2023). In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex. Nature, 616(7955):199-206.
3. Zongqiang Li, Shuaijiabin Chen, Liang Zhao, Guoqiang Huang, Xiong Pi, Shan Sun, Peiyi Wang, Sen-Fang Sui* (2022). Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Cell Research, 32(5):437-450.
4. Chenchen Mi, Li Zhang, Guoqiang Huang, Guangcan Shao, Fan Yang, Xin You, Meng-Qiu Dong, Shan Sun*, Sen-Fang Sui* (2022). Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Science Advances, 8(4): eabi5603.
5. Sen-Fang Sui* (2021). Structure of Phycobilisomes. Annual Review of Biophysics, 50:53–72.
6. Jianfei Ma, XinYou, Shan Sun, Xiaoxiao Wang, Song Qin, Sen-Fang Sui* (2020). Structural basis of energy transfer in Porphyridium purpureum phycobilisome. Nature, 579(7797):146-151.
7. Xiong Pi, Songhao Zhao, Wenda Wang, Desheng Liu, Caizhe Xu, Guangye Han, Tingyun Kuang*, Sen-Fang Sui*, Jian-Ren Shen* (2019). The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex. Science，365(6452). pii: eaax4406.
8. Xuan Huang, Shan Sun, Xiaojing Wang, Fenghui Fan, Qiang Zhou, Shan Lu, Yong Cao, Qiu-Wen Wang, Meng-Qiu Dong, Jun Yao, Sen-Fang Sui* (2019). Mechanistic insights into the SNARE complex disassembly. Science Advances, 5(4):eaau8164.
9. Jun Zhang, Jianfei Ma, Desheng Liu, Song Qin, Shan Sun*, Jindong Zhao, Sen-Fang Sui*. (2017). Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551(7678):57-63.
10. Shan Sun, Lin Li, Fan Yang, Xiaojing Wang, Fenghui Fan, Mengyi Yang, Chunlai Chen, Xueming Li, Hong-Wei Wang, Sen-Fang Sui*. (2017) Cryo-EM structures of the ATP-bound Vps4-E233Q hexamer and its complex with Vta1 at near-atomic resolution. Nature Communications, 8:16064.
版权所有 © 2020 北京生物结构前沿研究中心京ICP备15006448号-1
