陈春来 博士

副教授

主要科研领域与方向

1. 发展单分子荧光方法和技术；

2. 核糖体在蛋白质合成过程中翻译和调控机制的研究；

3. CRISPR系列蛋白靶向和剪切机制的研究。

代表性论文

1.     Jiawei Zhao ^#, Matthias Elgeti ^#*, Evan S. O’Brien, Cecília P. Sár, Amal EI Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L. Hubbell, Brian K. Kobilka*, and Chunlai Chen*, (2024) Ligand efficacy modulates conformational dynamics of the µ-opioid receptor, Nature, 629, 474–480

2.     Shouyue Zhang^#, Ao Sun^#, Jing-Mei Qian^#, Shuo Lin^#, Wenjing Xing, Yun Yang, Han-Zhou Zhu, Xin-Yi Zhou, Yan-Shuo Guo, Yun Liu, Yu Meng, Shu-Lin Jin, Cheng-Ping Li, Zhaofu Li, Shuai Jin, Jian-Hua Wang, Meng-Qiu Dong, Caixia Gao, Chunlai Chen*, Yang Bai*, Jun-Jie Gogo Liu*, (2024) Pro-CRISPR PcrIIC1 associated Cas9 system for enhanced bacterial immunity, Nature, 630, 484-492

3.     Wenjing Xing^#, Danyuan Li^#, Wenjuan Wang, Jun-Jie Gogo Liu *, Chunlai Chen*, (2024) Conformational dynamics of CasX (Cas12e) in mediating DNA cleavage revealed by single-molecule FRET, Nucleic Acids Research, gkae604

4.     Yuan Zhang^#, Chen Yang^#, Sijia Peng, Jing Ling, Peng Chen, Yumiao Ma, Wenjuan Wang, Zhixing Chen*, and Chunlai Chen*, (2023) General strategy to improve the photon budget of thiol-conjugated cyanine dyes, Journal of the American Chemical Society, 145, 7, 4187-4198

5.     Ruirui Sun, Yuqian Zhao, Wenjuan Wang, Jun-Jie Gogo Liu, and Chunlai Chen*, (2023) Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage, Chem Sci, 14, 3839-3851

6.     Xiaolin Niu, Zhonghe Xu, Yufan Zhang, Xiaobing Zuo, Chunlai Chen* and Xianyang Fang*, (2023) Structural and dynamic mechanisms for coupled folding and tRNA recognition of a translational T-box riboswitch, Nat Commun, 14(1), 7394

7.     Jie Heng, Yunfei Hu, Guillermo Pérez-Hernández, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixà-González, Changwen Jin, Peter W Hildebrand, Chunlai Chen*, and Brian K. Kobilka*, (2023) Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor, Nat Commun, 14(1), 2005

8.     Xiaolin Niu^#, Ruirui Sun^#, Zhifeng Chen, Yirong Yao, Xiaobing Zuo, Chunlai Chen* and Xianyang Fang*, (2021) Pseudoknot length modulates the folding, conformational dynamics and robustness of Xrn1 resistance of flaviviral xrRNAs, Nat Commun, 12, 6417

9.     Sijia Peng^#, Weiping Li^#, Yirong Yao^#, Wenjing Xing, Pilong Li* and Chunlai Chen*, (2020) Phase separation at the nanoscale quantified by dcFCCS, PNAS, 117(44):27124-27131

10.  Sijia Peng^#, Xiaowei Wang ^#, Lu Zhang ^#*, Shanshan He, Xin Sheng Zhao*, Xuhui Huang* and Chunlai Chen*, (2020) Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov State Models, PNAS, 117(36):21889-21895