闫创业 博士

副教授
教育部青年学者
树兰医学青年学者
求是青年学者
清华大学学术新人
2018-2021年连续四年入选科睿唯安高被引学者

主要科研领域与方向

1. 冷冻电镜方法的开发及应用

2. 重要膜转运蛋白的结构与功能研究

3. 真核细胞中剪接体的结构和功能以及前体信使RNA剪接机制的研究

代表性论文

1.   Yuan Y^#, Kong F^#, Xu H, Zhu A, Yan N, and Yan C^*. (2022). Cryo-EM structure of human glucose transporter GLUT4. Nat Commun 13, 2671.

2.   Wang N^#, Jiang X^#*, Zhang S, Zhu A, Yuan Y, Xu H, Lei J, and Yan C^*. (2021). Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell 184, 370-383 e313.

3.   Yan R^#, Cao P^#, Song W^#, Qian H, Du X, Coates H.W, Zhao X, Li Y, Gao S, Gong X, Yan C^* and Yan N^*. (2021). A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science.

4.   Yan C^#, Wan R^#, Shi Y. (2019). Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome. Cold Spring Harb Perspect Biol, doi: 10.1101/cshperspect.a032409.

5.   Bai R^#, Wan R^#, Yan C^#, Lei J, Shi Y. (2018). Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science, 360(6396): 1423-1429.

6.   Zhan X^#, Yan C^#*, Zhang X#, Lei J, Shi Y. (2018). Structure of a human catalytic step I spliceosome. Science,3 59(6375): 537-545.

7.   Zhang X^#, Yan C^#, Hang J^#, Finci LI, Lei J, Shi Y. (2017). An Atomic Structure of the Human Spliceosome. Cell, 169(5): 918-929.

8.    Yan C^#, Wan R^#, Bai R^#, Huang G, Shi Y. (2017) Structure of a yeast step II catalytically activated spliceosome. Science, 355(6321): 149-155.

9.   Yan C^#, Wan R^#, Bai R^#, Huang G, Shi Y. (2016). Structure of a yeast activated spliceosome at 3.5 A resolution. Science ,353, 904-911

10. Yan C^#, Hang J^#, Wan R^#, Huang M, Wong CC, and Shi Y. (2015). Structure of a yeast spliceosome at 3.6-angstrom resolution. Science , 349, 1182-1191, doi:10.1126/science.aac7629 (2015).