向烨 博士

副教授
国家杰出青年基金获得者

主要科研领域与方向

利用交叉学科的优势，结合冷冻电子显微镜, X-射线晶体学及分子与细胞生物学的方法，系统性地研究复杂生物大分子（如病毒）组装及行使功能的分子机制。同时，基于结构研究基础，开展以结构为导向的疫苗及药物开发。目前研究集中于天然免疫抗病毒分子机理及乙肝、丙肝病毒等复杂生物大分子组装及行使功能的分子机制。

代表性论文

1.     Duanfang Cao, Bingting Ma, Ziyi Cao, Xiaoyu Xu, Xinzheng Zhang*, Ye Xiang*. The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes. Nature Communications, 2024 15:6866.

2.     Qi Jia, Ye Xiang*. Cryo-EM structure of a bacteriophage M13 mini variant. Nature Communications, 2023 14:5421.

3.     Duanfang Cao, Bingting Ma, Ziyi Cao, Xinzheng Zhang*, Ye Xiang*. Structure of Semliki Forest virus in complex with its receptor VLDLR. Cell, 2023 186(10):2208-2218.

4.     Silian Chen, Miao Rong, Yun Lv, Deyu Zhu*, Ye Xiang*. Regulation of cGAS activity by RNA-modulated phase separation. EMBO reports, 2023 24(2):e51800.

5.     Bingting Ma, Cuiqing Huang, Jun Ma, Ye Xiang*, Xinzheng Zhang*. Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3. Nature, 2021 598(7882):677-681.

6.     Jingjing Gao, Miao Gui*, Ye Xiang*. Structural intermediates in the low pH-induced transition of influenza hemagglutinin. PLoS Pathog., 2020 16(11):e1009062.

7.     Qi Liu, Bingting Ma, Nianchao Qian, Fan Zhang, Xu Tan, Jianlin Lei, Ye Xiang*. (2019). Structure of the African Swine Fever Virus major capsid protein p72. Cell Research, 2019 29:953-955.

8.     Jingwei Xu, Dianhong Wang, Miao Gui, Ye Xiang*. Structural assembly of the tailed bacteriophage varphi29. Nat Communications, 2019 10:2366.

9.     Jingwei Xu, Nir Dayan, Amir Goldbourt*, Ye Xiang*. Cryo-electron microscopy structure of the filamentous bacteriophage IKe. Proc Natl Acad Sci U S A., 2019 116(12):5493-5498.

10. Wenfei Song, Miao Gui, Xinquan Wang*, Ye Xiang*. Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PLoS pathogens, 2018 14(8):e1007236. Google citation: 993.

11. Miao Gui, Wenfei Song, Haixia Zhou, Jingwei Xu, Silian Chen, Ye Xiang*, Xinquan Wang*. Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Research, 2017 27(1):119-129. Google citation: 672.

12. Jingwei Xu, Miao Gui, Dianhong Wang, Ye Xiang*. The bacteriophage phi29 tail possesses a pore-forming loop for cell membrane penetration. Nature, 2016 534(7608):544-547.