周瑞 博士

2017 国家奖学金
2017 清华大学结构生物学高精尖创新中心优秀博士生
2018 清华大学结构生物学高精尖创新中心卓越学者

主要科研领域与方向

阿尔兹海默症相关膜蛋白复合物γ- 分泌酶的结构与功能研究。

代表性论文

1.Rui Zhou*, Guanghui Yang*, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi. Recognition of the amyloid precursor protein by human γ-secretase. Science, 2019, 363(6428):eaaw0930.

2.Guanghui Yang*, Rui Zhou*, Qiang Zhou, Xuefei Guo, Meng Ke, Jianlin Lei, Yigong Shi. Structural basis of Notch recognition by human γ-secretase. Nature, 2019,565(7738):192-197.

3.Rui Zhou*, Guanghui Yang*, Yigong Shi. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization. Proceedings of the National Academy of Sciences, 114(48):12731-12736.