2025.11.24~2025.11.30
CNS刊登文章
01
Nature
本周无
02
Science
2025/11/27
“Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2”
mTOR 蛋白激酶形成两个多蛋白复合物——mTORC1 和 mTORC2，它们分别参与不同的信号通路。mTORC1 受营养物质调控，而 mTORC2 是磷脂酰肌醇-3 激酶（PI3K）和小 GTP 酶 Ras 信号网络中的关键节点，这些网络在癌症和糖尿病中常发生失调。尽管 mTOR 在体外能够磷酸化许多底物，但在细胞中，mTORC1 和 mTORC2 具有高度特异性：mTORC2 可磷酸化蛋白激酶 Akt 和 PKC，而不会作用于那些与之密切相关、却是 mTORC1 底物的激酶。
为了理解 mTORC2 如何识别其底物，来自美国波士顿布列根和妇女医院的Philip A. Cole，斯坦福大学医学院的Kacper B. Rogala以及俄亥俄州立大学综合癌症中心医学院的Nam Chu合作构建了半合成探针，用于捕获 mTORC2–Akt 复合物并解析其结构。大多数蛋白激酶通过识别磷酸化位点附近的氨基酸序列来识别底物，但对于 mTORC2 而言，局部序列对底物识别的贡献很小。相反，决定特异性的因素是 Akt 的二级和三级结构元素，这些结构在远离 mTOR 活性位点的位置与 mTORC2 组分 mSin1 结合，并且在至少 18 个相关底物中是保守的。这些结果揭示了 mTORC2 如何识别其经典底物，并可能为设计特异性针对 mTORC2 的抑制剂提供新的思路。
03
Cell
本周无
2025.11.24~2025.11.30
子刊刊登文章
01
Cell Research
本周无
02
Molecular Cell
本周无
03
Nature Structural & Molecular Biology
11.26
1.“TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1”
11.27
04
Nature Communications
11.24
1.“A ternary switch model governing ERα ligand binding domain conformation”
11.24
2.“Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex”
11.24
11.24
11.25
11.25
11.25
11.25
8.“Substrate recognition diversity and transport dynamics of ABCC1”
11.25
11.26
11.26
11.“Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference”
11.26
11.26
11.26
14.“Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis”
11.26
15. “Atomic mechanisms of full-length ASC-mediated inflammasome assembly”
11.26
16.“Structural basis for human chondroitin sulfate chain polymerization”
11.26
11.26
11.27
19.“Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy”
11.27
11.27
21.“Hierarchical folding-upon-binding of an intrinsically disordered protein”
11.28
22.“Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation”
11.28
23.“Structural insights into mechanisms of zinc scavenging by the Candida albicans zincophore Pra1”
11.28
24.“Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex”
11.28
11.28
26.“Structural basis of menaquinone reduction by succinate dehydrogenase from Chloroflexus aurantiacus”
11.28
11.28
11.28
29.“Visualizing the translation landscape in human cells at high resolution”
11.28
30.“Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors”
11.28
11.29
11.29
33.“Structural basis for MEKK2 dimerization and substrate recognition”
11.29
34.“Structural basis of sodium ion-dependent carnitine transport by OCTN2”
11.29
05
Science Advances
11.26
11.28
